FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF TASTE MASKED NIZATIDINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
The purpose of the research was to mask the intensely bitter taste of Nizatidine and to formulate Orodispersible tablet (ODT) and get rapid onset of action, to increase bioavailability and to increase patient compliance. Orodispersible tablets are an innovative technology, which disperse rapidly, usually in a matter of seconds, without the need for water, providing optimal convenience to the patient. The taste masking was done by complexing Nizatidine with methacrylate copolymer, Eudragit E100 in different ratios by mass extrusion method. The drug polymer complex was optimized by determining the drug content and in vitro drug release in simulated salivary fluid (SSF) of pH 6.8. Complex which did not release the drug in SSF was considered as the optimized batch and used for formulation of ODTs. The effects of various superdisintegrants such as Sodium Starch Glycolate, Croscarmellose sodium, Crosspovidone used in formulation of ODTs were studied. The formulation blend was evaluated for bulk density, tapped density, compressibility index, angle of repose etc. The ODTs were prepared by direct compression technique and evaluated for hardness, friability, wetting time, in vitro dispersion time, in vitro drug release etc. Among all formulation, F3 containing 5% w/w concentration of crosspovidone was considered to be the best formulation, with disintegration time of 34 seconds and in vitro drug release of 99.5% in 15 minutes in simulated gastric fluid (SGF). Thus, results conclusively demonstrated successful masking of taste and rapid disintegration of the formulated tablets.
Authors and Affiliations
Radhika Rajan, Pavani Makkena, Sivakumar Thangavel
Keywords
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