STUDY ON THE EFFECT OF GRAPE SEED PROANTHOCYANIDINS ON ADIPOCYTOKINE RECEPTORS IN DIET INDUCED FATTY LIVER DISEASE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 7
Abstract
Fatty liver is the hepatic component of the metabolic syndrome. Compelling evidence demonstrate that cytokines produced by the adipocytes play a major role in the pathogenesis of fatty liver disease. This study investigates effect of grape seed proanthocyanidins (GSP, 100 mg / kg b.w) in comparison and in combination with metformin (MET, 50 mg / kg b.w) on the mRNA levels in liver of major receptors of adipocytokines [tumor necrosis factor (TNF)-α, interleukin (IL)-6, adiponectin and leptin] in a rat model of high fructose, fat diet (HFFD)-induced fatty liver disease. HFFD-fed rats showed increased lipid content and oxidative stress with decreased antioxidants. The mRNA levels of receptors of TNF-α, IL-6 and leptin were also higher whereas that of adiponectin was lower during fatty liver disease. Upon GSP and MET administration, these changes in the receptor expression of adipocytokines were reversed. When both MET and GSP were administered, the effects were observed to be more intense. Restoration of the levels of adipocytokine’s receptors gives a clue, in part, of the ability of GSP and MET to combat fatty liver disease.
Authors and Affiliations
Yogalakshmi Baskaran , Anuradha Carani
Keywords
Related Articles
- EP ID EP135952
- DOI 10.7897/2230-8407.04744
- Views 60
- Downloads 0
DIURETIC ACTIVITY OF BUTEA MONOSPERMA FLOWERS EXTRACT
Kidney, as excretory organ of our body serves important function of excretion of waste products, regulation of fluid volume and electrolyte content etc. Damage to kidney can lead to severe life threatening complications....
FORMULATION DEVELOPMENT OF ORO-DISPERSIBLE TABLETS OF AYURVEDIC POWDER FORMULATION FOR EFFICIENT USE
The aim of this study was to formulate mouth dissolving tablets from Ayurvedic polyherbal powder Sitopaladi. Sitopaladi is a traditional Ayurvedic powder preparation well known and effective in relieving coughs associate...
APPLICATION OF SPHERICAL AGGLOMERATION TECHNIQUE TO IMPROVE MICROMERITIC PROPERTIES AND DISSOLUTION CHARACTERISTICS OF NABUMETONE
The present work is aimed to enhance the solubility and dissolution rate of Nabumetone, 4-(6-methoxy-2-naphalenyl)-2-butanone water insoluble anti-inflammatory drug by spherical agglomeration technique using a solvent ch...
ANALGESIC ACTIVITY OF LEAVES EXTRACTS OF SAMANEA SAMAN MERR., AND PROSOPIS CINERARIA DRUCE.
Current study was designed to explore the analgesic effects of methanol extracts of the leaves of Samanea saman Merr., and Prosopis cineraria Druce., using tail immersion test. The painful reactions in mice were produce...
ANTHELMINTIC SHANKHPUSHPI PELLETS: TASTE MASKING
Shankhpushpi is a highly potent anthelmintic drug having bitter taste. In the formulation for pediatric & geriatric patients the main challenge to the formulator is to mask the taste of obnoxious and bitter drugs wit...