FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF TRAMADOL HYDROCHLORIDE USING NOVEL CO-PROCESSED SUPERDISINTEGRANTS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 7
Abstract
In the present work, orodispersible tablets of Tramadol hydrochloride were prepared using novel co-processed superdisintegrants consisting of crospovidone and sodium starch glycolate in the different ratios (1:1, 1:2 & 1:3). The developed superdisintegrants were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be < 25o, Carr’s index in the range of 11-15% and Hausner’s ratio in the range of 1.12-1.17. Orodispesible tablets of Tramadol hydrochloride were prepared using the above co-processed superdisintegrants and evaluated for pre-compression and post-compression parameters. Based on in vitro disintegration time (approximately 18 sec), promising formulation CP1 was tested for in vitro drug release pattern in 0.1N HCl and drug excipients interaction (FT-IR spectroscopy, DSC) were studied. Among the designed formulations, the formulation (CP1) containing 4% w/w of co-processed superdisintegrant (1:1 mixture of crospovidone and sodium starch glycolate) emerged as the overall best formulation (t50% 1.46 min) based on drug release characteristics in 0.1N HCl compared to commercial conventional tablet formulation (t50%> 8 min).
Authors and Affiliations
Pravin Patil , Varsha More, Nagesh Tour
Keywords
Related Articles
- EP ID EP132955
- DOI 10.7897/2230-8407.06797
- Views 105
- Downloads 0
ROLE OF ASHWAGANDHA ON HEMATOLOGICAL, BIOCHEMICAL, SEMINAL PARAMETERS AND ON SERUM DHEA-S IN PSYCHOGENIC ERECTILE DYSFUNCTION PATIENTS
Ashwagandha (Withania somnifera Dunal) has been known for its capability to improve endurance against stress, general resistance against infections, to slow down the ageing process, improvement of male sexual health and...
ROLE OF INFORMATION TECHNOLOGY IN EDUCATION OF AYURVEDA: A REVIEW
With the growing popularity of Ayurveda worldwide, the approach towards teaching of Ayurveda needs a paradigm shift. This is to ensure that the global audience understands the concepts of the science in a language that i...
ANTIOXIDANTS OF CLOVE (SYZYGIUM AROMATICUM) PREVENT METAL INDUCED OXIDATIVE DAMAGE OF BIOMOLECULES
The present study evaluates the antioxidant potential of clove against copper induced lipid peroxidation, protein oxidative modifications and iron induced damage to DNA. 1, 1-diphenyl1-2 picryl hydrazyl free radical scav...
PENETRATION ENHANCEMENT OF MEDICINAL AGENTS
Many current therapeutic agents like antibiotics, ionizable and peptide drugs are impermeable or do not possess the requisite physicochemical properties for efficient transport through outer tissue barrier to attain ther...
PRODUCTION, PURIFICATION AND FUNCTIONALIZATION OF CARBON NANOTUBES FOR MEDICAL APPLICATIONS
Carbon nanotubes (CNTs) are needle-like potential carriers of bioactive including drug, genes and proteins. This review considers several techniques that have been developed for fabricating, purifying and functionalizing...