CHEMICAL MODIFICATION OF CHITOSAN AND FORMULATION OF ITS NANOPARTICLES FOR PROTEIN DRUG DELIVERY SYSTEM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 5
Abstract
The most common route of administration of proteins has been parenterals using invasive ways of administration but this route has many side effects like lack of patient compliance, cost, high drug levels etc. The development of an oral dosage form that improves the absorption of protein drugs is the most desirable formulation but one of the greatest challenges in the pharmaceutical field. The major barriers in developing oral formulations for peptides and proteins include poor intrinsic permeability, luminal and cellular enzymatic degradation and chemical and conformational stability. A number of innovative oral drug delivery approaches have been recently developed, including the drug entrapment within polymer nanoparticles. The various advantages of oral delivery of proteins are like ease of administration, can be used as cure in primary stages of disease eg. Thrombosis, no internal bleeding, patient compliance and economical Our formulation development approach is to develop the formulations targeted to bypass the stomach with an aim to release the drug in the intestine; with extended residence time in the GIT and for this polymer like Chitosan is used. To improve the lipophillic property of chitosan, to modify biodegradation pattern of polymer and for oral delivery of proteins (Insulin and serratiopeptidase), modification is done using lactic-acid and polyethyleneglycol by copolymerization.
Authors and Affiliations
Swastika Karwani, Rabindra Nanda, Jyoti Nirmal
Keywords
Related Articles
- EP ID EP98613
- DOI 10.7897/2230-8407.04534
- Views 116
- Downloads 0
NECK PAIN: AN ANCIENT VIEW
Neck pain is one of the very common complaints across the globe. Common neck pain occurs due to problems in the neck muscles, ligaments and discs due to faulty neck postures and daily neck misadventures accounting for mo...
CHEMICAL ANALYSIS OF NIRGUNDI TAILA WITH SPECIAL REFERENCE TO PREPARATION IN DIFFERENT NUMBER OF DAYS
Sneha kalpana is a process where the active principles present in the drug are extracted with the Sneha (Ghee or Oil) during the pharmaceutical process. The method of preparation of different Taila kalpanas requires diff...
COMPARISON OF LONG ACTING β2 - AGONISTS IN THE ASTHMATIC PATIENTS AND ASSESSMENT OF THEIR KNOWLEDGE, ATTITUDE AND PRACTICE
The study was conducted to evaluate the efficacies of the three long acting beta2-agonists (Salmeterol, Formoterol and Bambuterol) in south Indian population. This prospective multi-centered study conducted in various ho...
PHYTOSOME LOADED NOVEL HERBAL DRUG DELIVERY SYSTEM: A REVIEW
Novel drug delivery system (NDDS) is an innovative approach to drug delivery that addresses the limitations of the traditional drug delivery systems. If the novel drug delivery system is applied in herbal drugs, it shoul...
SUPPLEMENTATION OF VITAMIN E IMPROVES COGNITIVE STATUS AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS
Oxidative stress has been suggested as a major contributing factor for initiation and progression of cognitive impairment along with various other complications in type 2 diabetes mellitus. The present study was, therefo...