SUPPLEMENTATION OF VITAMIN E IMPROVES COGNITIVE STATUS AND OXIDATIVE STRESS IN TYPE 2 DIABETES MELLITUS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 11
Abstract
Oxidative stress has been suggested as a major contributing factor for initiation and progression of cognitive impairment along with various other complications in type 2 diabetes mellitus. The present study was, therefore, designed to assess the effect of vitamin E supplemention along with oral hypoglycaemic agents on cognitive functions and oxidative stress in patients with type 2 diabetes mellitus. A total of 74 type 2 diabetes mellitus patients were enrolled in this randomized open label controlled study from out-patient department of secondary care Government headquarters hospital, Ooty, India. Patients were randomised into two groups viz., control (n=36) and intervention (n=38). Control group received OHA’s i.e, Glibanclamide and/or Metformin. Patients in intervention group received OHA’s along with vitamin E supplementation (600mg/day) for a period of three months. Cognition functions were assessed for control and intervention group by using Mini Mental State Examination. Blood samples were analysed for the level of thiobarbituric acid reactive substances, superoxide dismutase, catalase, reduced glutathione and HbA1C by using specific assay methods at the baseline and by end of three months. Intervention group patients showed significant improvement in the orientation (9.22±0.27), p≤0.001 and in total MMSE score (28.00±0.43), p≤0.001 after three months of vitamin E supplementation. There was a significant decreased in lipid peroxidation and HbA1C level. Significant increase in enzymatic and non enzymatic antioxidant levels was observed in intervention group when compared to control group. Vitamin E supplementation is found to be effective in improving orientation, total MMSE score and oxidative stress in type 2 diabetes mellitus.
Authors and Affiliations
Anand Vijayakumar , Jayesh Bhatt , Jenny Varghese , Sushanta Das
Keywords
Related Articles
- EP ID EP140257
- DOI -
- Views 81
- Downloads 0
ANTIBACTERIAL ACTIVITY OF DIFFERENT EXTRACTS OF STEM BARK OF HOLOPTELEA INTEGRIFOLIA ROXB (PLANCH)
The petroleum ether, benzene, chloroform, methanol and aqueous extracts of the stem bark of Holoptelea integrifolia were evaluated for the antibacterial activity against various microorganisms viz Staphylococcus aureus,...
FISH CANCER DEVELOPED BY ENVIRONMENTAL POLLUTANTS
The pollution of rivers and streams with chemical contaminants has become one of the most critical environmental problems. Fish living in a polluted water reservoir use the contaminated water to rinse their gills; this r...
PROTECTIVE EFFECT OF ROOT EXTRACT OF NOTHOSAERVA BRACHIATA WIGHT IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS
In India, Berginia ligulata, Family Saxifragaceae is accepted source of ayurvedic drug Pashanabheda. Another species belong to Pashanabheda class is Nothosaerva brachiata Wight. The effect of oral administration of aqueo...
VETIVERIA ZIZANIOIDES (LINN.) NASH: A PHARMACOLOGICAL OVERVIEW
Vetiveria zizanioides is belonging to Poaceae family. It is well known plant from south India and widely distributed in India, Burma, Ceylon, and spread from Southwest Asia to tropical Africa. Vetiveria zizanioides is co...
NANOROBOTS IN BRAIN TUMOR
Nanomedicine is the process of diagnosing, treating, and preventing disease and traumatic injury, of relieving pain, and of preserving and improving human health, using molecular tools and molecular knowledge of the huma...