FORMULATION AND EVALUATION OF SOLID DISPERSION CONTAINING ASPIRIN
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 6
Abstract
Objective: The objective of the study is to increase the solubility by solid dispersion method and to compare dissolution of pure drug and solid dispersions.Aspirin (Acetyl Salicylic Acid)is poorly soluble in water show dissolution limited absorption and causes gastrointestinal (GI) irritation. Solubility enhancement of poorly aqueous soluble drugs is an important aspect of formulation development. Methods: The present study is an attempt to enhance the solubility of aspirin by fusion (Melt) method using aspirin and polyethylene glycol 6000 as a carrier in the ratio of 1:1, 1:2, 1:3 and 1:4. The complex of aspirin with polyethylene glycol6000 shows enhanced solubility than the pure drug and the complex can also reduce the gastrointestinal irritation.Micromeritic properties of granules were evaluated as well as dissolution rate studies were performed in phosphate buffer pH6.8.Results: Micromeritic properties of granules were found in specified limits. The dissolution rate was found tobe 95.94 1.17% for optimized formulation F4 at the end of 90 mins. Conclusion: It is concluded that dissolution of the aspirin could be improved by the solid dispersion and PEG6000 based solid dispersions were more effective in enhancing the dissolution.
Authors and Affiliations
chinmayakeshari sahoo, k. satyanarayana, d. venkataramana
Keywords
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