Formulation and evaluation of soyalecithin based emulsomes for topical administration of Lornoxicam
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2016, Vol 4, Issue 1
Abstract
The current objective of the research activity is formulation of Soyalecithin based Emulsomal Nanoparticles for percutaneous administration of Lornoxicam for better management against pain, especially inflammatory diseases of joints. In the present work the I.R peaks were observed for the physical mixture of Lornoxicam was almost identical when compared to that of the pure sample of Lornoxicam indicating their compatibility. Thin-film hydration, followed by High speed homogenization techniques were adopted for the formulation of Lornoxicam Emulsomes. Drug entrapment efficiency of formulation “F6” was found to be higher i.e., 67.75% when compared to the other formulations. All the formulations of Lornoxicam emulsomes followed first order kinetics, ascertaining Peppas mechanism and Higuchi’s mechanism by conducting In-vitro diffusion studies. Further the formulations to have non-Fickian diffusion and Super - Case II transport system based on ‘n’ values. Based on the release studies of all the formulations, F6 was considered to be the optimized formulation with the release of 88.81±0.46% at 72Hr.The particle size of the formulation F6 was observed to be 80.4nm which indicates that, the formulation was in Nano range. On the basis of the results, the formulation F6 was considered as the better formulation (% Entrapment efficiency- 67.75%, Zeta Potential- -57.3mv and % Drug diffusion -88.81±0.46%) for the effective management against pain especially inflammatory diseases of joints.
Authors and Affiliations
Nagasreenu Kommana M. Kishore Babu
Keywords
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