FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF TRAMADOL HYDROCHLORIDE AND STUDY IT’S RELEASE (DISSOLUTION) KINETICS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 8
Abstract
The objective of this work was to develop sustained release tablets of highly water soluble Tramadol HCl using polymers (HPMC K100M, HPMC K15M, Sodium Carboxy Methyl Cellulose, Polyethyleneoxide-N-80) as cost effective, non toxic easily available and suitable hydrophilic matrix system. Tramadol is a centrally acting analgesic drug, Due to high frequency of drug administration (4–6 hourly), small dose (50–100 mg) and short biological half-life (6 h) rationally call for the development of its sustained release. Highly soluble and permeable, this drug can be safely regarded as a BCS class I therapeutic agent.In order to optimize the various parameters 9 different formulations of SR layer were prepared and compressed separately. Sustained release tablet of Tramadol HCl (dose 100mg) were produced by wet granulation method. The drug release studies were performed using USP apparatus type І using pH 1.2 buffer and pH 6.8 phosphate buffer as dissolution medium. The best fit release kinetics was achieved with the zero order plot followed by the Zero order, First order, Hixon Crowel, Higuchi and Korsmyer and Peppas equation. The data obtained proved that the formulations are useful for a sustained release of Tramadol HCl due to the percentage released after 24 hr. is nearly to 100%. The drug release was dependent on the type and concentration of the polymer.
Authors and Affiliations
Mayur Aher, Ashish Jain , Pravin Kumbharde, Navnath Jadhav
Keywords
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