FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF ZIDOVUDINE
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
Zidovudine is widely used in ART as Nucleoside Reverse Transcriptase Inhibitors. In the present investigation an attempt has been made to design and develop Zidovudine S.R. tablets using various synthetic and natural hydrophilic polymers. Sustained release matrix tablets are prepared using Xanthan gum, HPMC K100M, Guar gum alone and in a combination by using direct compression method. A total of 7 formulations (3 formulations with Xanthan gum, HPMC, Guar gum respectively, 4 formulations containing HPMC and guar gum in combination with Xanthan gum in the ratio of 5:5 and 2.5:7.5 respectively) were prepared. All these prepared tablets are evaluated for weight variation, friability, thickness, hardness, drug content and drug release pattern. No significant variation from I.P. and U.S.P. limits was observed. The drug-excipient interaction studies were carried out by FTIR spectroscopy, DSC and visible inspection (by keeping drug excipient mixture for 1 month at room temperature). No significant interaction between rug and excipients was observed. The comparative evaluations of the dissolution profiles were done. From the data it was concluded that all formulations show Fickian diffusion or anomalous type drug release pattern. Of all the formulations F6 is the best formulation .From the above, it was concluded that few of the formulations (F1, F5, F6, and F7) follow the sustained release pattern of drug release.
Authors and Affiliations
K. Urukundu , N. Srinivas
Keywords
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