FORMULATION AND EVALUATION OF TASTE MASKED RAPIDLY DISINTEGRATING TABLET CONTAINING FLUPENTIXOL DIHYDROCHLORIDE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 9
Abstract
The aim of the present study was to develop rapid disintegrating tablets of Flupentixol dihydrochloride, a slightly bitter antipsychatric drug. An attempt has been made to prepare bitterless rapid disintegrating tablet using Eudragit E100 as a taste masking agent. The tablet was prepared with three superdisintegrants e.g. sodium starch glycolate, crosscarmellose sodium and crospovidone , each one was added in three different concentration 2%, 3% and 4% ; mass extrusion was the technique used for the preparation of these tablets. The blend was examined for angle of repose, bulk density, tapped density, compressibility index and Hausner’s ratio. The compressed tablets were evaluated for hardness, drug content, friability, disintegration time in-vitro and in-vivo, wetting time and dissolution rate. The contents of the prepared tablets were characterized by X-ray diffraction and Fourier transform infrared spectroscopy (FTIR). Different nine formulas showed in-vitro disintegration times ranges from 11.8 sec to 61 sec , but it was 150 sec for F1 ( formula without any superdisintegrant). These results were nearly correlated with in vivo disintegration times for the ten formulas. In vitro dissolution studies showed the release in the following descending order of superdisintegrants: Crospovidone > Croscarmellose sodium > Sodium Starch Glycolate. Maximum in vitro dissolution rate was found to be with formulation F10 which contains crospovidone (4%). Thus, F10 was considered the best among the other formulations. The stability study was conducted as the International Conference on Harmonization (ICH) guidelines and the formulations subjected again for changes in hardness, friability, drug content, wetting time and disintegration time. Crospovidone at a concentration of 4% w/w is suitable for preparing rapid disintegrating tablet of Flupentixol dihydrocloride.
Authors and Affiliations
Elbary Ahmed , Ramadan Afaf , Bendas Ihab , Abd Elaty Dalia
Keywords
Related Articles
- EP ID EP97774
- DOI -
- Views 84
- Downloads 0
EVALUATION OF ROLE OF SHIROBHYANGA WITH REFERENCE TO KESHA SWASTHYA (HEALTH OF NORMAL HAIR)
Abhyanga is one of the procedures to be practiced routinely in the system of once living. It is the most commonly indicated and extensively applied treatment procedure amongst the Bahirparimarjana Chikitsa. It reduces fa...
PRODUCTION OF α-AMYLASE FROM ASPERGILLUS FLAVUS UNDER SOLID STATE FERMENTATION WITH OPTIMUM CONDITIONS
α-amylases are ubiquitous enzymes produced by plants, animals and microbes, where they play a dominant role in carbohydrate metabolism. In spite of the wide distribution of amylases, microbial sources, namely fungal and...
A CRITICAL REVIEW ON KAKANDOLA: AN AYURVEDIC HERB
Kakandola, since ages has been used on the name of the herb named kapikachhu, for its medicinal properties. It is said to have the gunas like that of masha (Phaseolus mungo Linn.) and is used for its vrishya karma. In ma...
PURIFICATORY PROCESSES OF GANDHAKA (SULPHUR) AS DESCRIBED IN THE MEDIEVAL INDIAN TEXT ANANDAKANDA
Anandakanda a Rasasastra text of the medieval period illustrated six Gandhaka Shodhana (Purification of Sulphur) methods by using different dravyas, yantras, putas and samskaras. Among the six methods of Shodhana one met...
CONCEPTUAL STUDY OF THE EFFECT OF ‘UTTARBASTI’ IN ‘VANDHYATVA’ WITH SPECIAL REFERENCE TO CERVICAL FACTOR OF INFERTILITY
The most disappointing feeling for a woman is, if she could not be a mother. The present day’s life style of women is very stress full, unhealthy and unhygienic due to unawareness, hectic and fast running schedule. Vandh...