Formulation and evaluation of Telmisartan orodispersible tablets by using banana powder
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 1
Abstract
The aim of this research is to introduce and evaluate natural excipient (banana powder) that has versatile property in the orally disintegrating tablets using Telmisartan as model drug. Oral disintegrating tablets are the useful formulations for pediatrics, geriatric, psychiatric, patients and those have difficulty in swallowing tablets/capsules resulting in improved patient compliance. Telmisartan is an antihypertensive drug which belongs to the class of Angiotensin Receptor ΙΙ (Type- ATΙ) Antagonist. It is a poorly soluble drug (BCS class-II) and its absorption is dissolution rate limited. The oral bioavailability of Telmisartan is 45%. Hence, in this investigation an attempt was made to develop Oral dispersible tablets of Telmisartan formulated with natural disintegrating agent like banana powder with superior dissolution properties when compared to the Telmisartan ODTs formulated with synthetic superdisintegrant like SSG. The aim is to formulate various batches of oral disintegrating tablets of Telmisartan by using Banana powder and SSG with different concentrations 2%, 4%, 6%, individually by using different diluents like Mannitol and Lactose by wet granulation method. The tablets were evaluated for the precompression parameters such as bulk density, compressibility, angle of repose etc and post compression parameters like hardness, weight variation, friability, disintegration time and in-vitro dissolution profiles.Tablets containing banana powder as disintegrating agent were dispersed rapidly within 15 sec and showed 92.09% drug release in 15 min.
Authors and Affiliations
A. Bharathi, Sd. Khaleel Basha. K. N. V. Deepthi and M. CH. Phanindra
Keywords
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- EP ID EP33184
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