FORMULATION AND IN-VITRO EVALUATION OF LORNOXICAM IMMEDIATE RELEASE AND DICLOFENAC SODIUM SUSTAINED RELEASE BILAYERED TABLETS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The aim of the present work is to prepare bilayered tablet of Lornoxicam and Diclofenac sodium for treatment of rheumatoid arthritis. The bilayered tablet of which Lornoxicam is immediate layer and Diclofenac sodium is sustained release layer was prepare by direct compression due to good flow properties of the prepared blend. Initially drug is release from immediate release layer and loading dose is provideded by slow release of drug from sustained layer.the sustained release of drug is attained by the use of polymers like HPMC k100, metolose, manucol among this three polymers metolose shows better drug release. The prepared tablets were evaluated for post compression studies like thickness, hardness, friability, drug content, weight variation and invitro dissolution studies which show satisfactory results all are within the limits. The in-vitro dissolution studies were carried out by using type-2USP dissolution apparatus using 0.1N hydrochloric acid and 7.4 pH phosphate buffer as dissolution mediums for lornoxicam and diclofenac sodium. Among all the formulations f7 shows better drug release in intial hours and sustained drug action upto 12hrs.The drug release from optimized formulation followed zero-order, Higuchi model which indicates drug release from bilayered was Fickian diffusion. In conclusion, results indicate that prepared bilayered tablet could perform therapeutically better than conventional and sustained tablets with improved efficacy and better patient compliance.
Authors and Affiliations
B. Manikanta Anil, K. Narendra Kumar reddy
Keywords
Related Articles
- EP ID EP33108
- DOI -
- Views 309
- Downloads 0
Formulation development and evaluation of mefenamic acid microemulsion
The present study was conducted to formulate Microemulsion of Mefenamic acid using Tween 80 as surfactant. Various formulations were prepared using pseudo ternary phase diagram and analysed. The thermodynamic stability...
Effect of ethanol/water extract of Crinum jagus on glycemia, lipids parameters and body weight gain on high-sugar diet fed rats
Crinum jagus is used in Cameroon western region folk medicine in the management of diabetes and obesity. The effects of ethanol/water extract of C. jagus were evaluated on two month old Wistar rats submitted to a high...
Synthesis and pharmacological evaluation of 5-substituted-2,4-thiazolidinedione
The aim of present study is to synthesize a set of 5-substituted-2,4-thiazolidinediones as antimicrobial. These compounds were evaluated for their antimicrobial activity. The structures of the new derivatives were esta...
Biomimetics in dentistry – a review
Otto Schmitt in the 1950’s coined the term “Biomimetics” while studying the nerves in a squid. He tried to copy and design an artificial device that could replicate the same process of synaptic impulse. It literally me...
Development and Validation of Related Substances Method for Febuxostat Tablets by RP-HPLC
The present paper describes about highly sensitive, linear, precise, rugged, accurate and robust RP-HPLC method for determination of related substances present in Febuxostat tablets. Chromatographic separation with sep...