Synthesis and pharmacological evaluation of 5-substituted-2,4-thiazolidinedione
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 5
Abstract
The aim of present study is to synthesize a set of 5-substituted-2,4-thiazolidinediones as antimicrobial. These compounds were evaluated for their antimicrobial activity. The structures of the new derivatives were established on the basis of IR and NMR spectral studies. The increasing identification of antibiotic resistant pathogens that cause serious infections cannot be ignored. Although the future cannot be predicted with certainty, it is surely possible that an extensive epidemic resistant bacterial infection could potentially harm millions of people. As various infections are the challenge for medical science, like HIV, Hepatitis C, and various bacterial infections (gram negative and gram positive), the 2, 4-thiazolidinediones can be the key to problem. As 2,4-thiazolidinedione is containing Nitrogen in the Heterocyclic ring it must possess antimicrobial activity because we know that various antimicrobials and antibiotics like β lactam ring, alkaloids and quinoline rings are having Nitrogen in the heterocyclic ring.
Authors and Affiliations
Navjot Singh Sethi, Amerendra Singh, R. Parthasarthy
Keywords
Related Articles
- EP ID EP33252
- DOI -
- Views 308
- Downloads 0
Purification of Quercetin by HPLC from green tea leaves and its application in cancer therapy
Quercetin is the subject of intense research on the basis of its antioxidant, anti-inflammatory and anti-cancer activities. Antioxidant potential of Green tea (Camellia sinensis) leaves was checked by various antioxida...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF OLMESARTAN MEDOXOMIL BY RP-UPLC IN BULK AND PHARMACEUTICAL DOSAGE FORMS
A simple rapid, accurate, precise and reproducible validated reverse phase UPLC method was developed for the determination of Olmesartan medoxomil in bulk and pharmaceutical dosage forms. The quantification was carried...
DEVELOPMENT AND VALIDATION OF RP-HPLC METHOD FOR THE DETERMINATION OF CEFDINIR IN BULK AND CAPSULE DOSAGE FORM
A simple, specific, accurate, rapid, inexpensive isocratic Reversed Phase-High Performance Liquid Chromatography (RP-HPLC) method was developed and validated for the quantitative determination of Cefdinir in pharmaceut...
Green nanotechnology and its goal
Nanotechnology revolutionize all sorts of sciences includes industry which includes electronics medicine and consumer products. It involves in controlling the all the dimensions of understanding manipulation and contro...
Prevalence & comparison of Cigarette smoking habits among health care professional students
Smoking cigarette is by far the most important risk factor for oral cancer and pre cancer & its use is a medical addictive condition. Several meta-analyses of the impact of smoke free legislation have been published ov...