Synthesis and pharmacological evaluation of 5-substituted-2,4-thiazolidinedione
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 5
Abstract
The aim of present study is to synthesize a set of 5-substituted-2,4-thiazolidinediones as antimicrobial. These compounds were evaluated for their antimicrobial activity. The structures of the new derivatives were established on the basis of IR and NMR spectral studies. The increasing identification of antibiotic resistant pathogens that cause serious infections cannot be ignored. Although the future cannot be predicted with certainty, it is surely possible that an extensive epidemic resistant bacterial infection could potentially harm millions of people. As various infections are the challenge for medical science, like HIV, Hepatitis C, and various bacterial infections (gram negative and gram positive), the 2, 4-thiazolidinediones can be the key to problem. As 2,4-thiazolidinedione is containing Nitrogen in the Heterocyclic ring it must possess antimicrobial activity because we know that various antimicrobials and antibiotics like β lactam ring, alkaloids and quinoline rings are having Nitrogen in the heterocyclic ring.
Authors and Affiliations
Navjot Singh Sethi, Amerendra Singh, R. Parthasarthy
Keywords
Related Articles
- EP ID EP33252
- DOI -
- Views 284
- Downloads 0
FORMULATION AND EVALUATION OF ORO DISPERSIBLE TABLETS OF AMLODIPINE BESYLATE
Recent advances in technology have presented viable dosage forms alternative for patients who may have difficulty in swallowing tablets or capsules. Oro-dispersible tablet is one such approach in which the tablets were...
Design & characterization of candesartan Celexetil loaded solid lipid nanoparticles for effective management against CVS disorders
The present work aims to formulate solid lipid nanoparticles loaded with candesartan celexetil for the increase in the efficiency against cardio vascular disorders and increase the retention time to control the fluctua...
Review on effect of combination drug therapy on diabetes mellitus and its management
Diabetes is a chronic condition associated with abnormally high levels of sugar (glucose) in the blood. Insulin produced by the pancreas lowers blood glucose. Absence or insufficient production of insulin causes diabet...
Formulation and evaluation of Diclofenac potassium transdermal patches for enhanced therapeutic efficacy
Today 74% of the drugs are taken orally and are found not to be safe or effective as desired because they produce wide ranging fluctuation in drug concentration in blood stream. Continuous I.V infusion is recognized as...
Analytical method development and validation of Artesunate and Amodiaquine hydrochloride in tablet dosage form by RP-HPLC
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the simultaneous determination of Artesunate (ART) and Amodiaquine hydrochloride (AMO) in pharmaceutical do...