FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ANTIHYPERTENSIVE DRUG METOPROLOL SUCCINATE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The present research work is an attempt to develop and evaluate matrix-type transdermal therapeutic system of metoprolol succinate. It has a relatively greater blocking effect on beta 1-receptors.Transdermal patches of metoprolol succinate were developed with different ratios of hydrophilic - HPMC and hydrophobic –EC polymer combinations by solvent evaporation technique. The Fourier transform infrared spectroscopy (FTIR) was used to confirm compatibility and to rule out any possible interactions between drug and polymers. Ten transdermal patch formulations consisting HPMC K 15 M and Ethyl Cellulose were prepared. All formulations carried Dimethyl Sulfoxide as penetration enhancer and Dibutyl Phthalate as plasticizer and dichloromethane and methanol as solvent system. The prepared patches were evaluated for their physicochemical characteristics such as weight variation, thickness, folding endurance, percentage moisture absorption, percentage moisture loss, and drug content and In- vitro drug diffusion studies. Data of In - vitro drug diffusion from patches were fit in to different equations and kinetic models to explain release kinetics. The Cumulative drug release from Formulation K10 was found to be (97.36±1.089), after 24 hrs. So the formulation K10 is emerged as ideal formulation for metoprolol succinate because it showed better release with sustained effect as compared to other formulations.
Authors and Affiliations
Koteswararao P, Duraivel S, Sampath Kumar KP, Debjit Bhowmik
Keywords
Related Articles
- EP ID EP33135
- DOI -
- Views 275
- Downloads 0
Amlodipine: the upcoming threat to Periodontist
Gingival hyperplasia is one of the side effects commonly caused by three major groups of drugs such as a) anticonvulsants b) antihypertensives – calcium channel blockers c) immunosuppressants. Previously among antihype...
FORMULATION AND EVALUATION OF FENOFIBRATE TABLETS PREPARED BY EMPLOYING BIOAVAILABILITY ENHANCEMENT TECHNIQUE
Developing novel methods to increase the bioavailability of drugs that inherently have poor aqueous solubility is a great challenge to solid dosage form formulators. Although numerous methods are available to improve t...
Design and development of Telmisartan transferosomes
The aim of this research activity is to formulate Soyalecithin based transfersomal nanoparticles for percutaneous administration of Telmisartan for better management against cardiovascular diseases. The I.R peaks obtai...
FORMULATION, OPTIMIZATION AND IN-VITRO EVALUATION OF NIFEDIPINE SUSTAINED RELEASE TABLET
The objective of the present study was to develop sustained release tablet of Nifedipine. The drug is a dihydropyridine derivative mainly indicated for the treatment of Hypertension. The drug belongs to the therapeutic...
RECENT TRENDS OF POLYMER USAGE IN THE FORMULATION OF ORODISPERSIBLE TABLETS
Disintegrants are an essential component to tablet formulations. While rapidly disintegrating tablets do not necessarily ensure fast bioavailability, slowly disintegrating tablets almost always assure slow bioavailabil...