FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ANTIHYPERTENSIVE DRUG METOPROLOL SUCCINATE
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The present research work is an attempt to develop and evaluate matrix-type transdermal therapeutic system of metoprolol succinate. It has a relatively greater blocking effect on beta 1-receptors.Transdermal patches of metoprolol succinate were developed with different ratios of hydrophilic - HPMC and hydrophobic –EC polymer combinations by solvent evaporation technique. The Fourier transform infrared spectroscopy (FTIR) was used to confirm compatibility and to rule out any possible interactions between drug and polymers. Ten transdermal patch formulations consisting HPMC K 15 M and Ethyl Cellulose were prepared. All formulations carried Dimethyl Sulfoxide as penetration enhancer and Dibutyl Phthalate as plasticizer and dichloromethane and methanol as solvent system. The prepared patches were evaluated for their physicochemical characteristics such as weight variation, thickness, folding endurance, percentage moisture absorption, percentage moisture loss, and drug content and In- vitro drug diffusion studies. Data of In - vitro drug diffusion from patches were fit in to different equations and kinetic models to explain release kinetics. The Cumulative drug release from Formulation K10 was found to be (97.36±1.089), after 24 hrs. So the formulation K10 is emerged as ideal formulation for metoprolol succinate because it showed better release with sustained effect as compared to other formulations.
Authors and Affiliations
Koteswararao P, Duraivel S, Sampath Kumar KP, Debjit Bhowmik
Keywords
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