Formulation development and evaluation of matrix tablets of propranolol HCl by using release retarding agents
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 2
Abstract
The main aim of the present work is to formulate and develop matrix tablets of Propranolol HCl. Selected suitable method for preparation process of Direct compression method for matrix tablets of Propranolol HCl by using varying concentrations of HPMC K4M, HPMC K100M, sodium alginate and Xanthan gum as a release retarding agents,dibasic calcium phosphate, Microcrystalline cellulose as diluents, talc and magnesium stearate as glidant and lubricant. Excipients compatibility studies were carried out by Stability studies and FT-IR studies between API and selected excipients. All the matrix tablets of Propranolol HCl formulations were evaluated for Pre-compression and post-compression parameters. All the formulations were evaluated for the hardness, friability, thickness, weight variation,drug content uniformity, and in-vitrodrug release studies. Based on in-vitro drug release the polymer Xanthan gum showed better dissolution control compared to the other polymers like HPMC K4M and HPMC K100M and sodium alginate.Release of Propranolol HCl from the tablets formulated by employing 25mg of Xanthan gum and 77 mg dibasic calcium phosphateshowed that more drug release So, the formulation F-10 was the optimized formula. The release kinetics of all formulations showed that the drug release followed fickian and non-fickian transport.The release kinetics of optimized formula showed fickian transport followed by zero order.
Authors and Affiliations
Syed Hussain, G Soma Sekhar, R. Nazemoon, SmdRazia, Pattan Imran Khan
Keywords
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