Ethosomes: novel vesicular carriers for enhanced transdermal drug delivery of candesartan cilexetil
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2015, Vol 3, Issue 1
Abstract
The aim of this research activity is to formulate egg phosphatidyl choline based ethosomes for percutaneous administration of Candesartan cilexetil for the better management against cardiovascular disorders. The IR peaks obtained for the physical mixture of Candesartan cilexetil, was mostly identical with the pure sample of Candesartan cilexetil indicating their compatibility. Candesartan ethosomes were formulated by employing emulsification followed by high speed homogenization technique. Drug entrapment efficiency was found to be increased with increased in concentrations of egg phosphatidyl choline further. It was observed that the drug entrapment efficiency increased up to 30% v/v ethanol and decreased upon the rise in the concentration of the ethanol. In vitro diffusion studies of all the formulations revealed that the Candesartan cilexetil ethosomes followed first order kinetics and ascertained peppas mechanism. Application of the korsemeyer-peppas equation to the data of the formulations revealed that the mechanism of Candesartan cilexetil ethosomes was governed by predominant non-fickian diffusion (0.5>n<0.85) for all the formulations. Based on the % entrapment efficiency and the invitro diffusion data, the formulation ‘F7’ was found to be the optimized one. Further the particle size of Candesartan cilexetil was found to be 252.7nm indicating well within the ethosomal range. The zeta potential value of the formulations is found to be in the range of -24.8Mv indicating high negative surface charge leading to higher stability.
Authors and Affiliations
M. Kishore Babu, T. L. Tejaswini, V. Kameswara Rao, V. Pradeep, Mohan Krishna. D
Keywords
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