Formulation and evaluation of Zolmitriptan controlled release matrix tablets
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
Controlled release formulations in many case provide significant advantages, including improved therapeutic effect, increased patient compliance by reducing dosing frequency and decrease in incidence and or intensity of adverse effect by a constant blood concentration. The main objective of the present study was to develop controlled release matrix tablet formulation containing 5mg of Zolmitriptan for the treatment of migraine. The prepared tablets were then subjected to dissolution test for evaluating the in vitro drug release. The dissolution studies were carried out in 0.1 N HCl in USP II apparatus at 37±0.5°C. The results of the dissolution studies indicated that the polymer concentration was having a substantial effect on the drug release from the tablets. Formulation F14 which contained HPMC K15 (20%) and CAP have better controlled drug release (99.7% at 12 hours) and in comparison to the other formulations.
Authors and Affiliations
Ch. Sudha Venkata Posi Lakshmi, K. Narendra Kumar Reddy*, V Hema
Keywords
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