Formulation and Evalution Of Sustained Release Effervescent Floating Tablets of Nateglinide
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2018, Vol 8, Issue 4
Abstract
Nateglinide is a novel, exceedingly physiologic, glucose regulator lately ratified for the handling of type-2 diabetes mellitus. Nateglinide has a rapid commencement and diminutive duration of insulinotropic action those outcomes in decline of glucose level. The persistence of this study is to develop a floating tablet of Nateglinide to boost its bioavailability and sustained action. Tablets were prepared by direct compression method, using Ethyl cellulose, Carbopol 930 and pvpk-30. Tablets were evaluated for in vitro drug release features like hardness, thickness, friability, weight variation and floating properties. Additional tablets were evaluated for In vitro drug release studies for 24 hours. The tablets unveiled controlled and prolonged release while moving over the dissolution medium, polymer rearrangement played a critical role.
Authors and Affiliations
Tellagorla Thriveni, H. V. Gangadharappa, Panchumarthy Ravisankar2, Akhil Nair, K. Leelavathi2
Keywords
Related Articles
- EP ID EP381287
- DOI -
- Views 90
- Downloads 0
Impact of Prehypertension on Carotid Artery Intima Media Thickness
: Background: Recent evidence supports that the prehypertension is associated with target organ damage, though there is lack of information regarding common carotid artery intima media thickness (CIMT) in prehype...
[b]A histological study on acrylamide and cadmium chloride altered chick embryonic liver[/b]
Optimization of Nutrient Components for Tacrolimus Production by Streptomyces tsukubaensis using Plackett-Burman followed by Response Surface Methodology
Tacrolimus belongs to macrolide lactone groups isolated from Streptomyces tsukubaensis, is used to prevent organ transplantation rejection. The aim of this study was to enhance the production of Tacrolimus by opt...
Pattern of aural morbidity among children in a rural tertiary care hospital
To study the pattern of aural morbidity among the paediatric population attending the ENT OPD of our hospital.Methods:DESIGN: Observational study with a cross-sectional design SETTING: Tertiary government rura...
Hepatoprotective Activity of Flavonoids Purified and Ethanolic Extract from Iraqi Propolis Against Carbon tetrachloride-Induced Liver Damage In Male Mice
The present study aims to investigatethe antioxidant activity of flavonoids purified and methanolic extract from propolis on male mice compared to that caused by carbon tetrachloride as a hepatotoxic model by measu...