FORMULATION AND IN-VITRO EVALUATION OF EFFERVESCENT FLOATING MATRIX TABLETS OF NIZATIDINE USING NATURAL AND SEMI SYNTHETIC POLYMERS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
The aim of this study was to develop a floating gastroretentive dosage form using effervescent technique so as to increase the patient compliance and to provide a prolonged therapeutic effect. Nizatidine was used as a model drug because of its short elimination half-life and localized action in the gastric region. Nine batches containing 75mg of Nizatidine per tablet were developed using release modifiers like xanthan gum and HPMC K100M both individually and in 1:1 combination at 30, 40 and 50% concentrations. Sodium bicarbonate and tartaric acid were used as gas generating agents. The drug-excipient compatibility, pre and post compression parameters, buoyancy properties and swelling index were evaluated. In-vitro dissolution studies were carried out in 0.1N HCl (pH 1.2) at 37±0.5oC. Increase in polymer concentration showed significant retardation of drug release and increase in swelling property. Release kinetics were studied by fitting the data into various models and release mechanism, predicted drug release were studied. Best formulation among the designed batches was selected based on cumulative percentage of drug released by the end of twelfth hour and by comparing the predicted and obtained drug releases at the end of 5th and 8th hours respectively.
Authors and Affiliations
Sarat Chandra, PM Vasanth, T Ramesh, M Ramesh
Keywords
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