Formulation and In-vitro Evaluation of Fast Disintegrating Tablet of Eprosartan Mesylate
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2018, Vol 7, Issue 2
Abstract
In the present work, fast dissolving tablets of Eprosartan Melysate were prepared by direct compression method with a view to enhance patient compliance. One super-disintegrants, viz., crospovidone use in different ratios with microcrystalline cellulose along with directly compressible mannitol to enhance mouth feel. The prepared batches of tablets were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time (approximately 13s), nine formulations batches were tested for the in vitro drug release pattern (in pH 6.8 phosphate buffer), short-term stability (at 40°/75% relative humidity for 6 month) and drug-excipient interaction (IR spectroscopy). Among the nine promising formulations, the formulation prepared by using 10% w/w of crospovidone and 35% w/w of microcrystalline cellulose emerged as the overall best formulation (t50% 1.8 min) based on the in vitro drug release characteristics compared to conventional commercial tablet formulation (t50% 16.4 min). Short-term stability studies on the formulations indicated that there were no significant changes in drug content and in vitro dispersion time. Keywords: Fast dissolving tablets, Eprosartan melysate , Crospovidone, Microcrystaline cellulose
Authors and Affiliations
S. B. Humane
Keywords
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