Formulation and In-Vitro Evaluation of Immediate Release Tablets of Losartan Potassium Using Different Superdisintegrants
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 2
Abstract
In the present study an attempt has been made to prepare the various trails (T1 to T7) of immediate release tablets of losartan potassium by using a suitable diluent (Microcrystalline cellulose PH 101), a binder (Pregelatinised starch 1500) with different superdisintegrants (Crospovidone, Croscarmellose sodium and Sodium Starch Glycollate). The formulation development work was initiated with wet granulation. The prepared granules and tablets were evaluated for various pre and post compression parameters such as loss on drying, bulk density, tapped density, compressibility index, Hausner’s ratio, particle size distribution, Weight variation, Tablet hardness, Thickness, Friability, Disintegration time, Drug content and in-vitro dissolution study. It was concluded that the immediate release tablets with proper hardness, disintegration time and with an increase rate of dissolution can be made using Crospovidone (T6). The optimized formulation (T6) is further selected and compared with the in-vitro release profile of the innovator product with various dissolution media such pH 1.2, pH 4.5 and pH 6.8. The results were found to be satisfactory.
Authors and Affiliations
J. Vinod*| Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India., A. Chenthilnathan| Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli, Tamil Nadu, India.
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