Abstract

Aim: The current paper was an attempt to design a sustained release dosage form using various grades of hydrophilic polymers, Hypromellose (hydroxyl‑propyl methylcellulose HPMC K4M, HPMC K15M and HPMC K100M) and Povidone K30 as binder solution in a matrix‑controlled drug delivery system of Lamivudine. Materials and Methods: Laboratory scale batches of six tablet formulations were prepared by wet granulation technique. Micromeritic properties of the granules were evaluated prior to compression. Tablets were characterized as crushing strength, friability, weight variation, thickness, drug content or assay and evaluated for in‑vitro release pattern for 24 h using buffer (PH-1.2) followed by Phosphate buffer of pH 6.8 at 37 ± 0.5°C. The in‑vitro release mechanism was evaluated by kinetic modeling. Results and Discussion: The results obtained revealed that HPMC K4M at a concentration of 25% in formulation (F2) was able to sustain the drug release for 24 h and followed the Higuchi pattern. There was no such major chemical interaction found between the drug and excipients during Fourier Transform Infrared Spectroscopy (FTIR) study. Conclusion: Hence, combinely HPMC K4M and Povidone K30 at a suitable concentration can effectively be used to sustain drug release.

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