FORMULATION AND IN -VITRO EVALUATION OF ORALLY DISINTEGRATING TABLETS OF LEVOCETIRIZINE HYDROCHLORIDE
Journal Title: IJAR-Indian Journal of Applied Research - Year 2017, Vol 7, Issue 12
Abstract
Levocetirizine Hydrochloride is an anti-allergic agent under the class of anti-histamines. In current research work oral disintegrating tablets of Levocetirizine Hydrochloride were prepared with Sodium starch glycolate, L-HPC LH 11, Crospovidone as superdisintegrants in different concentrations using direct compression method. The blend was examined for the pre-compression parameters and the values obtained were within prescribed USP limits. The prepared tablets were evaluated for various parameters like Thickness, weight variation, hardness, friability, disintegration time, drug content, water absorption ratio, wetting time, and in vitro drug release. The values obtained in post-compression parameters were within the prescribed USP limits. Based on the results obtained, the formulation containing 10% Crosspovidone (CP3) was identified as an ideal and better formulation because it had exhibited faster wetting time, good taste and faster disintegration time (19.6 sec) when compared to all other formulations. The in vitro drug release of optimized formulation CP3 was found to be 98% at the end of 15 min, 50 % of drug was released within 3.5 min and 90 % of drug was in 9.4 min. The results concluded that oral disintegrating tablets of Levocetirizine hydrochloride shown enhanced dissolution rate, which improves bioavailability, effectiveness and hence better patient compliance.
Authors and Affiliations
L. Srilatha, B. Deepika, Kandukoori Naga Raju
Keywords
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