FORMULATION AND INVITRO/ INVIVO EVALUATION OF DRIED NANOSUSPENSIONS OF NEBIVOLOL
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract In the present study, an attempt was made to prepare oral Nanosuspension of Nebivolol (a beta1 blocker), in order increase drug solubility and to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. Nanosuspension containing the drug was prepared by precipitation method using combinations of polymers (such as tween 80, tween 20, soluplus, PEG 200, PEG 400 and methanol) in to 12 formulations F1to F12. Subsequent drying was done by spray drying method to form dried nanosuspensions. The Nanosuspensions were evaluated for particle size, zeta potential, drug content uniformity, in-vitro drug release, short-term stability, and drug- excipient interactions (FTIR). IR spectroscopic studies indicated that there are no drug-excipient interactions. The formulation F10 containing Tween 80, Tween 20, Soluplus, PEG 200, PG, Methanol and water were found to be promising, which showed 100% drug release within 15 min when compared to the optimised formulation (Bystolic) which showed only 91.95% drug release for 20mins. SEM (scanning Electron Microscopy) analysis showed average particle size to be at 300.3nm and it also shown desired zetapotential value. Short-term stability studies indicated stability with respect to drug content and dissolution. Dried Nanosuspension of nebivolol can be prepared by precipitation method and spray drying was done. Among all the formulations, F10 was found to be promising with 100% drug release in 15mins. Short-term stability studies of the promising formulation indicated that there are no significant changes in dissolution parameter values after 3 months.
Authors and Affiliations
S. Raja shekhar*1, P. Vijaya lakshmi2
Keywords
Related Articles
- EP ID EP330673
- DOI -
- Views 80
- Downloads 0
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT ACTIVITY OF SELECTED MANGO (MANGIFERA INDICA L.) AND AVOCADO (PERSEA AMERICANA) FRUITS IN ILLU ABABOR ZONE, OROMIA REGIONAL STATE, ETHIOPIA
Abstract Mango (Mangifera indica L.) and Avocado (Persea americana) fruits are rich in bioactive molecules that protect human cells against the detrimental effect of free radicals. The phytochemical analysis revealed the...
GARBHINI PARICHARYA (ANTE-NATAL CARE) – VIEW OF HARITA SAMHITA (A TREATISE OF 10th CENTURY)
Abstract Woman, being the precious creation of the world is the only source for new creation. To procreate a healthy progeny is one of the esteem desire of a woman. Pregnancy although being a physiological phenomenon, st...
DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR SIMULTANEOUS DETERMINATION OF PARITAPREVIR, RITONAVIR AND OMBITASVIR IN FIXED TABLET DOSAGE FORM
Developing a single analytical method for the estimation of individual drugs is very challenging, due to the formation of drug-drug and drug-excipient interactions. The present study demonstrates the applicability of the...
Design and Evaluation of Extended Release Capsules of Acetazolamide Using Eudragit RS100 And Eudragit RL100
Utilizing the concept of incorporating drug in to the polymer matrices and extend the drug release for prolong period of time, an attempt was made to design and evaluate extended release capsules of acetazolamide using e...
Review Article: Novel Approach for Colon Targeted Drug Delivery
Colonic drug absorption, as an alternative to parenteral drug delivery, is evaluated for its potential advantages and limitations. Methodologies for studying and enhancing colonic drug absorption are discussed with empha...