Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2016, Vol 4, Issue 3
Abstract
Objective: To deal with the formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet containing Carica papaya, Vitex negundo, Moringa oleifera and Boswellia serrata used as a novel drug delivery system. An attempt has been made to develop polyphyto matrix tablets by using HPMC & ethyl cellulose. Methods: Pharmacological screening of polyphyto matrix tablet was evaluated by using the carrageenan-induced paw edema rat model and the study carried out by using various doses (100, 200 & 300 mg/kg body weight) of three different polyphyto matrix formulations. Diclofenac sodium was used as a standard drug, due to its considerable report on anti-inflammatory importance. Data were expressed by mean±SD; statistical analysis was performed by using ANOVA and p<0.05 considered as statistically significant. Results: Physical and chemical evaluation parameters of polyphyto matrix formulation exhibits potent and dose-dependent anti-inflammatory activity in all the tested animal groups. Formulation F1 significantly (p<0.05) suppresses the inflammation in the rat paw and found to be preeminent and stable in comparison with standard and other two (F2 & F3) formulations. Conclusion: Study reveals that the polyphyto matrix formulation could be useful as either an alternative or a complementary therapy in the management of all types of inflammation. It may be due to presence of terpenoids, alkaloids, glycosides and other phytochemical in herbs.
Authors and Affiliations
Harikesh Maurya| Department of Pharmaceutical Sciences, Kumaun University, Nainital (UK) India, Tirath Kumar| Department of Pharmaceutical Sciences, Kumaun University, Nainital (UK) India
Keywords
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