FORMULATION DEVELOPMENT AND EVALUATION OF ABACAVIR LOADED POLYMETHACRYLIC ACID NANOPARTICLES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
Nanoparticles render a promising drug delivery system of controlled and targeted drug release. These are specially designed to release the drug in the vicinity of target tissue. The aim of this present study was to develop and evaluate polymethacrylic acid nanoparticles containing nanoparticles abacavir in different drug to polymer ratio by nanoprecipitation method. SEM indicates that nanoparticles have a discrete spherical structure without aggregation. The average particle size was accurately found to be 120 ±9 - 403 ±3 nm. The particle size of the nanoparticles was gradually increased with increase in the proportion of polymethacrylic acid polymer. The drug containing nanoparticles was increasing on increasing polymer concentration up to a particular concentration ratio. No difference was observed in the extent of degradation of product during sixty days in which, nanoparticles were stored at various temperatures. FT-IR studies indicated that there were no chemical interaction between drug and polymer and stability of drug. The in-vitro release character from all the drug loaded batches was found to be zero order and rendered sustained release over a period of 24 h. The prepared formulations overcome and breakup the drawbacks and limitations of abacavir sustained release formulations and could possibility be advantageous in terms of increased bioavailability and efficacy of abacavir.
Authors and Affiliations
Dheivanai S. L. , Jeevaprakash G. , Nallathambi R. , Selva kumar, Senthilvelan S.
HERBAL INDICATORS AS AN UPCOMING TREND IN TITREMETRIC ANALYSIS
Indicators are very special chemicals, they will change color of the solution with change in pH by adding acid or alkali. Red cabbage is actually blue in color. It will be quite blue when slice it up and add some tap wat...
GAS CHROMATOGRAPHY TROUBLESHOOTING STRATEGY FOR ANALYTICAL CHEMISTRY
The most utilized of all the chromatographic techniques is gas chromatography. This technique gives good precision and accuracy. Essentially a gas chromatography separates of a gaseous mixture in a column and detects the...
PREVALENCE OF DIABETES MELLITUS AND OBESITY AMONG POPULATION OF SULTANPUR KUNHARI AND ITS SURROUNDING AREA, HARIDWAR UTTARAKHAND
The burden of diabetes is to a large extent the consequence of macrovascular (coronary artery disease, peripheral vascular disease, and atherosclerosis) and microvascular (like retinopathy, neuropathy, and nephropathy) c...
SIMPLE UV SPECTROMETRIC FOR THE ESTIMATION OF METHOCARBAMOL IN BULK AND ITS FORMULATION
The objective of the work is to obtain a correct analytical method for analysis of active substance in bulk drug and in the finished product. From the literature survey, it was found that Methocarbamol used extensively i...
ANTIMICROBIAL ACTIVITY OF BIOSYNTHESIZED SILVER NANOPARTICLES PREPARED FROM THE LEAF EXTRACT OF LANTANA CAMARA
Lantana camara commonly known as weed or red sage is found throughout India. It was reported to be used in traditional medicine system for infectious diseases. The present study designed to evaluate antimicrobial activit...