FORMULATION DEVELOPMENT AND EVALUATION OF DEFERASIROX DISPERSIBLE TABLETS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 6
Abstract
Objective: The main objective of this work was designed to Formulate and evaluate the Deferasirox Dispersible tablets. Methods: Model drug is related to BCS class II drug (low solubility and high permeability), to increase the solubility of model drug, need to incorporate solubility enhancers like surfactants. The excipients selected for final formulation were compatible with model drug. The finalized formula was optimized and the final composition contains the following excipients like microcrystalline cellulose, Lactose mono hydrate, Cremophore, Povidone, Silicon dioxide, Crospovidone and Magnesium Stearate. Results: Model drug was characterized for Particle size distribution, bulk density and tapped density. The physical characterization reveals that API has very poor flow.Indicating that suitable granulation technology required for designing the dosage form.The tablet parameters like weight variation, hardness, thickness etc. were evaluated for all batches. Physical parameters of tablet were found to be satisfactory in all the batches. In vitro dissolution studies were performed for the determination of optimized formulation. Conclusion: The finalized formulation F19 had comparable dissolution profile to reference product. Finalized formulation F19 was stable when stored at 40°C/ 75% RH for 1M, 2M and 3M min HDPE container
Authors and Affiliations
s. saipriya, sasikanth kothamasu, manohar babu s
Keywords
Related Articles
- EP ID EP436317
- DOI -
- Views 151
- Downloads 0
THE KNOWLEDGE, ATTITUDES AND PRACTICES OF HOUSEWIVES TO THE WAYS OF PREVENTING MALARIA IN HEALTH CENTERS IN MEHRESTAN CITY–2016
Introduction: Malaria is one of the most important health problems in tropical and subtropical countries. Currently malaria is the most important parasitic disease in Iran which limited local transmission has been report...
EARLY DETECTION AND SCREENING FOR PROSTATE CANCER
Purpose: The purpose of this review was to understand etiology, epidemiology, risks and predisposing factors of prostate cancer, recognize tests for early detection and prevention of prostate cancer to use it in a clinic...
EVALUATION OF THE EFFECT OF BENZENE-CONTAMINATED WATER ON THE GRAVIMETRY, SERUM CHOLESTEROL AND TRIGLYCERIDE CONCENTRATIONS OF AFRICAN CATFISH (CLARIAS GARIEPINUS)
Objective: The biochemistry of Clarias gariepinus cultivated in benzene-contaminated water for a period of 8 weeks was studied. Methods: Twenty African catfish were divided into two groups of ten fish each and cultivated...
COGNITIVE ENHANCEMENT POTENTIAL OF AVERRHOA CARAMBOLA AGAINST MEMORY IMPAIRMENT IN RATS
Introduction: due to the significant increase in the dementia and Alzheimer’s diseasesrate in recent years, public health has been facing inmany countries of the world, one of the major problemscaused by this disease. Be...
MINERAL COMPOSITION OF LEAVES, ETHANOLIC LEAF EXTRACT AND INFUSIONS OF A. OCCIDENTALE L. FROM AMAZON IN NORTHERN BRAZIL
Objective: The present study aimed to evaluate the content of mineral elements of leaves, ethanolic extract and a tea infusion leaf of Anacardium occidentale L., known as cashew, has economic importance and is used for t...