Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL
Journal Title: International Journal of Trend in Scientific Research and Development - Year 2019, Vol 4, Issue 1
Abstract
Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29702/formulation-development-and-evaluation-of-oral-fast-dissolving-films-of-metaclopromide-hcl/zeenath-ruhy
Authors and Affiliations
Zeenath Ruhy
Keywords
Related Articles
- EP ID EP685785
- DOI -
- Views 124
- Downloads 0
Formation of Self Management Skills in Foreign Language Teaching
Teachers should remember to always try to involve those parents who are unable to be actively involved in the classroom throughout the class day. A positive classroom environment is an important tool for establishing a s...
A Study to Assess the Attitudes of Nonhealth Professional towards Nursing Profession in Pacific University Campus of Gwaliour City
BACKGROUND OF THE STUDYAccording to the researchers in the university of Michigan, the aim of the nursing community worldwide is for its professionals to ensure quality care for all, while maintaining their credentials,...
Investigating the Effectiveness of Construction Practices in Delayed Residential Projects in Gadhinglaj City through Time and Cost Perspective
Construction schedule delays could also be explained by means of the late completion of construction add comparison of designed schedule of project. If the explanations of the development projects schedule delay are foun...
Effectiveness of Demonstration on Practices Regarding Hand Hygiene among Mothers of Under Five Children in a Rural Area of Lucknow District
It has been found that washing hand with soap may prevent many common and life threatening infections. Interventions used to prevent diarrheal diseases, includes safe drinking water, use of improved sanitation and washin...
The Importance of Social Entrepreneurship of Profit Based Businesses towards its Brand Image and Reputation
International responsiveness is progressively being drained to Social Entrepreneurial Businesses SEOs . Ultimately, innovative types of businesses target to answer social, environmental or societal hitches by using conte...