FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE OXCARBAZEPINE TABLET
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2015, Vol 3, Issue 8
Abstract
The Sustained release drug delivery systems that are designed to achieve or extend therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose, to individualize treatment more effectively. Oxcarbazepine indicated as monotherapy or adjunctive therapy for the treatment of partial seizures with or without secondarily generalized tonic-clonic seizures in adults and children. The polymer hydroxy propyl methyl cellulose (HPMC) was selected. The other excipients were used are magnesium stearate used as lubricant, Polyvinylpyrrolidone used as binder of tablet, and cross carmellose sodium as super disintegration agent. Oxcarbazepine was prepared by wet granulation technique.
Authors and Affiliations
Sinha Sonali| Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, Goyal Kumar Anil| Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan, Satraval P. C. | Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan
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