Formulation development and evaluation of Telmisartan Nanoemulsion
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 4
Abstract
The aim of the present study was to development of oral nanoemulsion formulation of telmisartan belong to BCS class 2nd, It have low solubility and low permeability. Therefore, oral nanoemulsion containing Telmisartan was prepared to increase its solubility and bioavailability rate. The o/w nanoemulsion was prepared by screening the excipients from the nanoemulsion region of pseudo-ternary phase diagram. Oleic acid optimized as an oil phase based on higher solubility study. Surfactant (Tween 80) and co-surfactant (PEG 200) were mixed (Smix) in different volume ratios (1:1, 1:2, 1:3, 1:4, 2:1, 3:1..). The optimized formulation containing Oleic acid (13.6%), Tween 80 (23.9%), PEG 200 (7.9%) and Methanol (54.6%) as oil, surfactant, co-surfactant and aqueous phase in Smix was prepared. Formulated nanoemulsions has to be evaluated for UV, FTIR, in vitro drug release, viscosity, particle size, product stability at accelerated conditions compared to the conventional formulation. Optimized oral nanoemulsion showed increase bioavailability.
Authors and Affiliations
Rajesh Kumar| Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University Jhansi-284128 Uttar Pradesh India, Girish Chandra Soni | Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University Jhansi-284128 Uttar Pradesh India, S. K. Prajapati| Department of Pharmaceutics, Institute of Pharmacy, Bundelkhand University Jhansi-284128 Uttar Pradesh India
Keywords
Related Articles
- EP ID EP16029
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(4).2711-2
- Views 355
- Downloads 54
ELECTRONIC TRIAL MASTER FILE (eTMF) - AN INDISPENSABLE TOOL THAT COLLECTS AND FILES ESSENTIAL DOCUMENTS OF A CLINICAL TRIAL: A REVIEW
Every organization involved in clinical trials in the BioPharma industry maintains a trial master file comprised of thousands of pages of regulatory documents required for each clinical trial. Managing thousands of clin...
Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus
A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were syn...
Speciation, biofilm formation and antifungal susceptibility of Candida isolates
Recently, an increase in the incidence of infections caused by fungi especially non-albicans Candida species has been reported. Several virulence factors like biofilm formation, toxin production and presence of adhesin...
THE EFFECT OF CONSUMPTION OF DIFFERENT FOODS ON BODY MASS INDEX OF OVERWEIGHT WOMEN
Food pattern is one of factors influencing on incidence of chronic diseases such as colon cancer, hypertension, and vascular diseases. World health organization states that increase of obesity throughout the world threa...
Effect of Yogic exercise on static Spirometery values in normal healthy individuals
Introduction: Yogic practices can be a very good exercise for maintaining proper health and has a profound effect on the lung functions of an individual. They are also used as psycho-physiological stimuli to increase t...