PHARMACOLOGICAL INVESTIGATION OF LEAVES OF ANTHOCEPHALUS CADAMBA (ROXB) FOR HEPATOPROTECTIVE ACTIVITY
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2016, Vol 5, Issue 6
Abstract
The objective of the present investigation was to study hepatoprotective activity of ethanolic extract of leaves of Anthocephalus cadamba, paracetamol induced liver damage model in rats. In this study, liver damage in rats done by paracetamol(2g/kg b.w.) in Tween 80. The ethanolic extract of the plant was administered in rats daily for seven days. The biochemical parameters were investigated. Histopathological changes in liver were studied. Silymarine was used as a standard hepatoprotective agents. The result indicates that biochemical changes produced by paracetamol were restored to normal by ethanolic extract. The ethanolic extract of leaves of Anthocephalus cadamba (ROXB.) showed significant hepatoprotective effect againest paracetamol induced liver damage model in rats.
Authors and Affiliations
Ramji Swarnkar| Research scholar, Shri Venkateshwara University, Gajrula, Uttar Pradesh, India, S. K. Jain| Institute of pharmacy, Bundelkhand University, Jhansi, Uttar Pradesh, India, Pankaj Singh Niranjan| Research scholar, Shri Venkateshwara University, Gajrula, Uttar Pradesh, India, Suneel Kumar Niranjan| Research scholar, Shri Venkateshwara University, Gajrula, Uttar Pradesh, India
Keywords
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