Epidermal Growth Factor Receptor Mutations detection by Mutant Specific Immunohistochemistry in North Indian Lung Cancer population
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 6
Abstract
Background: Lung cancer is one of the leading causes of cancer-related deaths due to limited treatment options available for advanced-stage disease. The epidermal growth factor receptor is a trans-membrane glycoprotein having an extracellular epidermal growth factor binding domain and an intracellular tyrosine kinase domain which regulates signaling pathways to control cellular proliferation. Material and Methods: Detection of EGFR mutation status of 80 subjects of non-small cell lung cancer of adenocarcinoma subtype had been done by IHC using EGFR mutation specific antibodies. Results: 20 cases were positive for Del E746-A750 mutation, 6 for L858R mutation. IHC analysis shows that 30 cases scored 0, 12 cases scored 2+ and 8 cases scored 3+ in Del E746-A750 mutation while 24 cases scored 0, 1 case scored 2+ and 5 cases scored 3+ in L858R mutation. The mean age of mutation positive is 56±9.50 and negative is 53.37±11.83. 65.38% male and 34.61% female were positive for EGFR mutation. The study shows that 8 (30.77%) ex/ current smokers and 18 (69.2%) nonsmokers were positive for EGFR mutations. Conclusion: Patients who were positive for EGFR mutation can take gefitinib treatment instead of taking other chemotherapy regimen. This is a rapid method for diagnosis of lung cancer patients and helpful in the treatment decision which improve the burden of the disease.
Authors and Affiliations
Priyanka Gaur| Department of Physiology King George’s Medical University, Lucknow, India, Sandeep Bhattacharya| Department of Physiology King George’s Medical University, Lucknow, India, Surya Kant| Department of Respiratory Medicine King George’s Medical University, Lucknow, India, RAS Kushwaha| Department of Respiratory Medicine King George’s Medical University, Lucknow, India, Jyotsana Agarwal| Department of Microbiology, King George’s Medical University, Lucknow, India, Anumesh Kumar Pathak | Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India
Keywords
Related Articles
- EP ID EP16043
- DOI http://dx.doi.org/10.21276/IJRDPL.2278-0238.2017.6(6).2796-2
- Views 336
- Downloads 18
Formulation and characterization of mouth dissolving mucoadhesive buccal film of Zolmitriptan
Fast dissolving buccal film drug delivery system is an alternative to tablets, capsules, and syrups for pediatric and geriatric patients who experience in difficulties of swallowing traditional oral solid dosage forms....
EVALUATING MANAGEMENT SKILLS OF HEAD NURSES OF ZAHEDAN MEDICAL SCIENCES UNIVERSITY TRAINING HOSPITALS BY 360 DEGREES METHOD
In traditional method of evaluating hospitals head nurses’ capabilities like professionalism, communicational skill and interpersonal skill has been performed just by hospitals managers and without taking feedback fro...
Antioxidant properties of polyphenolic rich HPLC standardized extract of Beta vulgaris L. roots
OBJECTIVES: The present study was planned to evaluate the antioxidant effects of standardized Beta vulgaris L. or beetroot. METHODS: The polyphenols present in lyophilized water extract of beetroot (BR) were quantifie...
Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus
A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were syn...
FLOATING DRUG DELIVERY SYSTEM
The aim of writing this review on gastro retentive and floating drug delivery system was to compile the new literature with the principle mechanism of floatation to acquired gastric retention. Various attempts have been...