Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 2
Abstract
A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were synthesized by condensation of chalcone of indane-1,3-dione with phenyl hydrazine in basic medium in the presence of ethanol. The newly synthesized compounds (7a-f) have been characterized by IR and 1H-NMR Spectroscopy and TLC. The new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.
Authors and Affiliations
Siddharth S. Desai| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India, V. Girija Sastry| Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhaparnam- 530003, India, Ashok Malpani| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India, Kishore Singh| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India
Keywords
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