Synthesis, characterization, antimicrobial and antitubercular activity of Some Pyrazoline derivatives from Chalcones bearing indane-1,3-dione as nucleus
Journal Title: International Journal of Research and Development in Pharmacy & Life Sciences (IJRDPL) - Year 2017, Vol 6, Issue 2
Abstract
A series of phenyl pyrazoline derivatives have been synthesized from chalcones of indane-1,3-dione. The substituted chalcones have already been synthesized and reported by us. The phenyl pyrazoline derivatives were synthesized by condensation of chalcone of indane-1,3-dione with phenyl hydrazine in basic medium in the presence of ethanol. The newly synthesized compounds (7a-f) have been characterized by IR and 1H-NMR Spectroscopy and TLC. The new compounds have been evaluated for their antibacterial, antifungal and antitubercular activities.
Authors and Affiliations
Siddharth S. Desai| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India, V. Girija Sastry| Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Andhra University, Visakhaparnam- 530003, India, Ashok Malpani| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India, Kishore Singh| Department of Pharmaceutical Chemistry, Rajiv Memorial Education Society’s College of Pharmacy, Gulbarga-585102, India
Keywords
Related Articles
- EP ID EP16007
- DOI -
- Views 318
- Downloads 16
Speciation, biofilm formation and antifungal susceptibility of Candida isolates
Recently, an increase in the incidence of infections caused by fungi especially non-albicans Candida species has been reported. Several virulence factors like biofilm formation, toxin production and presence of adhesin...
Formulation and evaluation of Buccal patches of Furosemide
This study is mainly focused on the ability of polymer to increase the bioavailability of Furosemide and to release the drug in controlled predetermined manner. The polymers selected for the study include natural and s...
Cancer: An Overview
Cancer is the second leading causes of deaths in western countries after heart disease. In US alone more than one million people are diagnosed with cancer annually and more than half result in death. Cancer is a medica...
COMPARATIVE IMMUNOMODULATOR ACTIVITY OF LEAVES AND BARK OF ALBIZIA LEBBECK (LINN.) BENTH
Adaptability is probably the most distinct characteristics of life which may be defined as sum of all non specific response of the body to any demands made upon it; fundamentally it was a physiological response; primary...
Formulation development and evaluation of Telmisartan Nanoemulsion
The aim of the present study was to development of oral nanoemulsion formulation of telmisartan belong to BCS class 2nd, It have low solubility and low permeability. Therefore, oral nanoemulsion containing Telmisartan...