FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LAMIVUDINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
Two hydrophobic polymers Eudragit RL 100 and Eudragit RS 100 were used for preparing sustained release lamivudine tablet. In this study the effect of the thermal and solvent treatment on drug release, tensile strength was studied. Increasing the sintering duration increase in the sustained release and also increase in hardness of tablet. FTIR, XRD and DSC study shows no chemical interaction between drug and polymer and no polymorphic changes in drug due to sintering. SEM analysis conformed the redistribution of polymer and smoother tablet. The solvent treatment gives more sustained release of drug compare to thermal treatment.
Authors and Affiliations
Ramesh Katariya , Ravali Goli , Shilpa Chaudhari
Keywords
Related Articles
- EP ID EP119982
- DOI -
- Views 81
- Downloads 0
STUDIES ON ALMOND GUM BASED COLON TARGETED TABLETS OF SECNIDAZOLE AND ITS β-CYCLODEXTRIN COMPLEX TO TREAT AMOEBIASIS
The present investigation was planned to formulate colon targeted tablets of Secnidazole using almond gum as matrix carrier. Also, it was planned to improve the solubility of Secnidazole by forming inclusion complex with...
ENHANCEMENT OF SOLUBILITY OF TADALAFIL BY COCRYSTAL APPROACH
Cocrystallization is an emerging method to optimize physicochemical properties of pharmaceutically active compounds including dissolution rate and stability. The main aim of this study was to increase the solubility by c...
SPECIFIC AND NON-SPECIFIC IMMUNE RESPONSE AND DISEASE RESISTANCE OF SOLANUM TORVUM LEAF SOLUBLE FRACTIONS IN FRESHWATER CARP CYPRINUS CARPIO
The immunostumulatory effect of the leaves extract of a medicinal plant Solanum torvum (Turkey Berry), On Specific, non-specific immune responses and disease resistance of Common carp Cyprinus carpio was investigated. Fi...
DEVELOPMENT AND VALIDATION RP-HPLC METHOD FOR ANALYSIS OF FELODIPINE IN BULK AND PHARMACEUTICAL DOSAGE FORM
The aim of present study was to develop and validate new simple, easy, selective, precise and accurate reverse phase high performance liquid chromatography for the estimation of Felodipine in bulk and pharmaceutical dosa...
ESSENTIAL OIL COMPOSITION AND ANTIOXIDANT ACTIVITY OF LAVANDULA ANGUSTIFOLIA FROM IRAQ
The essential oil of Lavandula angustifolia Mill. growing spontaneously in Iraq was investigated by GC and GC/MS for the first time. The oil was extracted from the flowers by hydro-distillation. Thirty-four components am...