FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF LAMIVUDINE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
Two hydrophobic polymers Eudragit RL 100 and Eudragit RS 100 were used for preparing sustained release lamivudine tablet. In this study the effect of the thermal and solvent treatment on drug release, tensile strength was studied. Increasing the sintering duration increase in the sustained release and also increase in hardness of tablet. FTIR, XRD and DSC study shows no chemical interaction between drug and polymer and no polymorphic changes in drug due to sintering. SEM analysis conformed the redistribution of polymer and smoother tablet. The solvent treatment gives more sustained release of drug compare to thermal treatment.
Authors and Affiliations
Ramesh Katariya , Ravali Goli , Shilpa Chaudhari
Keywords
Related Articles
- EP ID EP119982
- DOI -
- Views 106
- Downloads 0
PENETRATION ENHANCERS: A NOVEL STRATEGY FOR ENHANCING TRANSDERMAL DRUG DELIVERY
Skin penetration enhancers have been used to improve bioavailability and increase the range of drugs to be administered by topical and transdermal route. Enhancement in skin penetration via modification of the stratum co...
SYNTHESIS AND ANTHELMINTIC ACTIVITY OF 3-(2-HYDRAZINO BENZOTHIAZOLES)-SUBSTITUTED INDOLE-2-ONE
Benzothiazoles and Isatins have emerged as structurally novel anthelmintics. Therefore various 3-(2-hydrazino benzothiazoles)-substituted Indole-2-one, were synthesized by condensation of various 2-hydrazino benzothiazol...
COMPARISON OF LONG ACTING β2 - AGONISTS IN THE ASTHMATIC PATIENTS AND ASSESSMENT OF THEIR KNOWLEDGE, ATTITUDE AND PRACTICE
The study was conducted to evaluate the efficacies of the three long acting beta2-agonists (Salmeterol, Formoterol and Bambuterol) in south Indian population. This prospective multi-centered study conducted in various ho...
ANALGESIC EFFECT OF ETHANOL EXTRACT OF HEDYOTIS CORYMBOSA L. WHOLE PLANT
This study was aimed to evaluate the possible analgesic properties of the ethanol extract of Hedyotis corymbosa L. (Rubiaceae) a locally available plant used in traditional medicine for the management of pain and other c...
CYTOTOXIC ACTIVITY OF AVOCADO SEEDS EXTRACTS (Persea americana MILL.) ON T47D CELL LINES
Avocado (Persea americana Mill.) is a widely grown plant that had been studied for several activities such as antioxidant and chemopreventive. The aims of this study were to analyze the secondary metabolite compounds con...