Formulation development and optimization of fast dissolving film containing carvedilol nanocrystals for improved bioavailability
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2018, Vol 8, Issue 6
Abstract
In this work, fast dissolving films (FDF) were prepared using nanocrystal formulations in order to optimise dissolution properties of lipophilic, poorly soluble drug Cavedilol. Drug nanocrystals are crystals with a size in the nanometer range, meaning that they are nanoparticles with a crystalline character. Carvedilol nanosuspensions were prepared using a high-pressure homogenizer, and then encapsulated in to films by solvent casting method using polymers such as maltodextrin and PVA in different concentrations. Propylene glycol used as a plasticizer. This study aimed to develop and evaluate the formulation of FDF containing Carvedilol nanocrystals for enhanced bioavailability and better compliance. The formulation of FDF was optimized by Box-Behnken Design (BBD) (design expert 11.03).In this design, 13 formulas were performed. One of the formula were suggested by design expert desirability = 1.
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- EP ID EP494988
- DOI 10.22270/jddt.v8i6.2017
- Views 81
- Downloads 0
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