FORMULATION DEVELOPMENT AND OPTIMIZATION OF OLMESARTAN MEDOXOMIL IMMEDIATE RELEASE TABLETS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2015, Vol 7, Issue 5
Abstract
Olmesartan Medoxomil blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor. ACE inhibitor is used in treatment of hypertension. The objective of the present study was to formulate an immediate release tablet of an antihypertensive drug, Olmesartan Medoxomil. Pre-formulation studies were carried out and results were within the limits. Tablets of Olmesartan Medoxomil were initially prepared by direct compression approach which resulted in poor flowability of the blend. Then the tablets were prepared by wet granulation techniques and the dissolution observed was on lower side. To obtain the desired dissolution pattern various trials had been taken with different excipients. Tablets were evaluated for their weight, hardness, friability, drug content, in-vitro dissolution. Similarity and dissimilarity factor were also calculated for Olmesartan Medoxomil with reference tablet. Stability study indicates that the formulation was stable.
Authors and Affiliations
Srikant Pimple, Akash Joshi, Pravin Maurya, Astik Swami, Mahesh Digge, Ruby Singh
Keywords
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