FORMULATION DEVELOPMENT AND OPTIMIZATION OF TABLET CONTAINING COMBINATION OF SALAM (SYZYGIUM POLYANTHUM) AND SAMBILOTO (ANDROGRAPHIS PANICULATA) ETHANOLIC EXTRACTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 3
Abstract
Objective: The present study was aimed at finding the appropriate type of a binder and a disintegrant which can be used formulate tablets containing a combination of two ethanol extracts of Syzygium polyanthum leaves and Andrographis paniculata herbs, as well as to find their optimum concentrations which would produce the tablets with desired hardness and disintegration time.Methods: Tablet manufacturing was done in two methods with the use of PVP K30 as a binder using the wet granulation method, and gelatin as a binder using the direct compression method. The design optimization used was the 22 full factorial designs with two factors and two levels, with the factors used being the binder concentration and the disintegrant.Results: Tablets produced using gelatin as a binder had a hardness level similar to those using PVP K30 as a binder. However, their disintegration time was strongly affected by the choice of the binder. The result suggested that different binder (PVP K30 and gelatin) affected different disintegration time despite producing tablet hardness values that were almost identical.Conclusion: The herbal tablet development of combined ethanolic extracts of Syzygium polyanthum and Andrographis paniculata herbs could be made using gelatin as a binder and crospovidone as a disintegrating agent using the direct compression method. The optimal formula was be obtained using gelatin 3.61% and crospovidone 3.45%, which had theoretical results in the hardness of 6.50 kp, the friability of 0.35%, and the disintegration time of 12.76 min.Keywords: Syzygium polyanthum, Andrographis paniculata, Gelatin, Crospovidone, Optimization
Authors and Affiliations
Lannie Hadisoewignyo, Lisa Soegianto, Martha Ervina, Indahwati Wijaya, Sari Dewi Santoso, Novi Tania, Lydia Andita Syawal, Raymond R. Tjandrawinata
Keywords
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