FORMULATION DEVELOPMENT AND STANDARDISATION OF HERBAL GEL CONTAINING METHANOLIC EXTRACT OF BUTEA FRONDOSA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 11
Abstract
The present research has been undertaken with the aim to formulate and evaluate the herbal gel containing Butea frondosa extract. The gel formulation was designed by using methanol extract of Butea frondosa stem barks in concentration (5%) and evaluated using physiological measurements. The gel was prepared by using accurately weighted amount of drug along with other additives were poured into the fixed amount of hydrated Carbopol-934 dispersion with constant stirring. Finally the required amount of 0.5M sodium hydroxide solution was added to induce gelation. All the prepared gel formulations were subjected for preliminary evaluation such as pH, Viscosity and Rheological studies, Spreadability, Drug content uniformity, Skin irritation test, In vitro diffusion study, In vitro permeation studies and Drug Polymer Compatibility Studies. The optimized herbal gel formulation of the drug was subjected to accelerated stability studies at both 40C and 370C for about 3 months. A suitable UV method was developed for herbal gel formulation by using Phosphate buffer 6.8 as solvent and max found to be 274 nm. The pH of all the formulations was in the range of 6.59 to 7.41, which lies in the normal pH range of the skin. The drug content was in the range of 96.4 to 99.6 %. The formulations did not produce any skin irritation, i.e., erythema and edema for about a week, when applied over the skin. The drug interaction FT-IR studies indicated that there was no chemical interaction between the drug and the polymers used in gel formulations.
Authors and Affiliations
Uma Mishra, P. N. Murthy , Gourishyam Pasa , Sanjay Kumar
Keywords
Related Articles
- EP ID EP150705
- DOI -
- Views 88
- Downloads 0
CONTRACEPTIVES IN GREEK LITERATURE: A REVIEW
The concept of contraception can be traced back since antiquity. Contraceptives are the agents or measures which are used to prevent conception. Unani physicians like Hippocrates, Aristotle, Dioscorides and Galen were we...
PROTECTIVE EFFECT OF ROOT EXTRACT OF NOTHOSAERVA BRACHIATA WIGHT IN ETHYLENE GLYCOL INDUCED UROLITHIATIC RATS
In India, Berginia ligulata, Family Saxifragaceae is accepted source of ayurvedic drug Pashanabheda. Another species belong to Pashanabheda class is Nothosaerva brachiata Wight. The effect of oral administration of aqueo...
FORMULATION DEVELOPMENT OF IRBESARTAN (POORLY WATER-SOLUBLE DRUG) IMMEDIATE RELEASE TABLETS
The aim of the present study is to increase the solubility of poorly water soluble drug Irbesartan by using surfactants and formulating into immediate release tablets by using super disintegrants. Surfactants such as sod...
ANTIOXIDANT ACTIVITY OF ETHANOLIC ROOT EXTRACT OF ANACYCLUS PYRETHRUM
The ethanolic extract of Anacyclus pyrethrum root was screened for invitro and exvivo antioxidant activities by using different experimental models .Safer antioxidants suitable for long term use are needed to prevent...
CONSERVATION OF BIO – DIVERSITY OF ULTAPANI FOREST RANGE UNDER HOLTUGAON DIVISION, MANAS BIOSPHERE RESERVE, ASSAM THROUGH COMMUNITY CONSERVATION PROGRAM
Ultapani is one of a “hotspot” area situated in Holtugaon forest division under Manas Biosphere Reserve, Assam. Ultapani forest range is located in between 26068.18// N to26081.18// N and 90024.44// E to 90041.90// E. Ve...