FORMULATION DEVELOPMENT OF IRBESARTAN (POORLY WATER-SOLUBLE DRUG) IMMEDIATE RELEASE TABLETS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
The aim of the present study is to increase the solubility of poorly water soluble drug Irbesartan by using surfactants and formulating into immediate release tablets by using super disintegrants. Surfactants such as sodium lauryl sulfate, polysorbate, and poloxamer 800 are used for increasing the solubility of drug in water by micellisation technique. Super disintegrant such as croscarmellose sodium was used for fast disintegration. Physical properties for granules such as Bulk density, Tapped density, Hausners ratio, % compressibility, % LOD and physical characteristics for Irbesartan IR tablets such as weight variation, friability, hardness, thickness, disintegration, in-vitro dissolution were studied. % cumulative drug release of formulation T3 (having 2% Tween 80) matched with the innovator product Avapro and the similarity factor between innovator and T3 was 97.
Authors and Affiliations
Lakshmi Abbaraju , Anand Meka , Vamshi Krishna, Annie Vijetha, Ashwini G.
Keywords
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