FORMULATION AND EVALUATION OF DENTAL GEL CONTAINING ESSENTIAL OIL OF CORIANDER AGAINST ORAL PATHOGENS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 10
Abstract
The objective of this study was to investigate the antimicrobial potency of essential oil of Coriander against clinical samples isolated from the oral cavity of various patients and to formulate a suitable topical preparation containing Coriander oil. A total of 41 swabs were obtained from patients (age between 20 - 50 years) which were diagnosed with oral infections like periodontal abscess, periapical abscess, chronic periodontities, periapical granuloma, dental caries, root caries and plaque samples. These samples were inoculated on Blood agar, Mac-conkeys agar and MRS Lactobacilli MRS agar, Mutans Sanguis agar, KF Streptococcal agar at 37°C for 24 – 48 h aerobically except for KF Streptococcal agar and Mutans Sanguis agar, which was incubated anaerobically at 37°C for 24 – 48 h. The isolates were identified by standard microbiological procedures. The samples had positive cultures of Streptococcus faecalis, Streptococcus sanguis, Streptococcus oralis, Streptococcus mutans, Streptococcus salivarius, Lactobacilli, CONS. The susceptibility of these isolates was determined using agar disc diffusion method for zone of inhibition. The evaluation of antimicrobial potency was studied prior to gel formulation to compare the changes in activity after incorporation in polymer gel. The topical formulations were developed using different concentrations of polymers and evaluated for various physicochemical parameters like pH, color, clarity, viscosity, consistency, homogeneity, spread ability. The activity of oil was not much affected by incorporation in gel. The gel showed promising antimicrobial activity against the strains used for the study.
Authors and Affiliations
Vinita Pawar , Trupti Bhagat , Mitesh Toshniwal , Nitin Mokashi , K. R Khandelwal
Keywords
Related Articles
- EP ID EP141461
- DOI 10.7897/2230-8407.041012
- Views 96
- Downloads 0
INHIBITION OF CALCIUM OXALATE CRYSTALLIZATION IN-VITRO BY VARIOUS EXTRACTS OF HYPTIS SUAVEOLENS (L.) POIT.
Hyptis suaveolens (L) Poit. commonly known as Vilayati tulsi, belongs to the Mint family Lamiaceae. The inhibition of in-vitro calcium-oxalate crystal (a major component of most urinary stones) formation by various extra...
PHARMACOLOGICAL SCIENTIFIC EVIDENCE FOR THE PROMISE OF TRIBULUS TERRESTRIS
The usage of plants, plant extracts or plant-derived pure chemicals for disease management, become a therapeutic modality, which has stood the test of time. In the present review, we focus on pharmacological profile (in...
ROLE OF FISH OIL AGAINST CANCER
Cancer represents the largest cause of mortality in the world as the millions of humans and animals die every year. Chemotherapy being a major treatment modality used for the control of advanced stages of malignancies an...
ANTI-FERTILITY ACTIVITY OF WHOLE PLANT EXTRACT OF SARCOSTEMMA SECAMONE (L) BENNET ON MALE ALBINO RATS
Anti-fertility effect of ethanol extract of whole plant extract of Sarcostemma secamone was observed in male albino rats. The relative weight of the testes and epididymis were decreased. The epididymal sperm count, motil...
IN VITRO PLANT REGENERATION OF CRITICALLY ENDANGERED MEDICINAL PLANT ARTEMISIA AMYGDALINA D.
An efficient in vitro propagation protocol for Artemisia amygdalina D. developed here resulted in the induction of significantly more number of shoots (36 shoots per nodal explant) on a medium containing 10 µM benzyl ami...