FORMULATION, EVALUATION, AND OPTIMIZATION OF NOVEL SILVER SULFADIAZINE LOADED FILM FORMING HYDROGEL FOR BURNS
Journal Title: Hygeia:journal for drugs and medicines - Year 2016, Vol 8, Issue 2
Abstract
Plan:Formulation, evaluation and optimization of Silver sulfadiazine loaded film forming hydrogel using different hydrophilic polymers for the treatment of burns. Preface: Burn injuries are very complex. One of the golden treatments in topical burn is silver sulfadiazine (SSD).The film forming hydrogels (FFHs) are non- solid dosage forms that produce a flexible, occlusive film in-situ after application on the skin or any other body surface. Methodology: The hydrogel matrix was prepared with combinations of PVA & PVP, HPMC E5LV, and HPMC E15LV. The prepared FFHs were evaluated for their various physicochemical properties. The optimized formulation was selected by antimicrobial activity by agar diffusion technique. The in-vitro drug release study of optimized formulation was carried out and analyzed by potentiometric titrations. Outcome: All the formulations showed better antimicrobial activity when compared with marketed SSD cream. The formulation F3 was found to be the optimized formulation.
Authors and Affiliations
SARANYA TV, Manoj K
Keywords
Related Articles
- EP ID EP333755
- DOI 10.15254/H.J.D.Med.8.2016.156
- Views 58
- Downloads 0
QUALITATIVE ASSESSMENT OF KAYATHIRUMENI - A SIDDHA MEDICATED OIL AS A REMEDY FOR ARTHRITIC PAIN
Plan: Kayathirumeni is an important formulation of Siddha system of medicine used to treat various human disorders. Such as myalgia, Arthritic pain etc. Preface: The present study aimed to set quality parameters in phys...
Synthesis, Anticancer Activity and Docking of somesubstituted Benzothiazoles as EGFR Tyrosine Kinase Inhibitors and Topoisomerase IIinhibitors
Plan:The present study focuses on the structure based drug design approach for anticancer activity of various substituted benzothiazoles whether as an EGFR TK inhibitor or as topoisomerase inhibitor. Preface: The develo...
OPTIMIZED TRI-LAYERED PULSATILE TABLET OF SALBUTAMOL FOR CHRONODELIVERY IN ASTHMA
Plan: The study was aimed to develop a tri-layered pulsatile tablet of salbutamol sulphate for Chrono therapeutic delivery in bronchial asthma. Incidence of asthma is greatest in the early morning hours referred as “morn...
Synthesis, characterization and anti-fungal potential evaluation of 1, 4 thiazine derivatives by Mannich bases.
Plan: The present research work is aimed to synthesize newer, less toxic and more effective Mannich bases of 1, 4 thiazine derivatives and further compare their antifungal activities. Preface: Microbial infections are b...
PHYTOCHEMICAL STUDIES OF BIOACTIVE COMPOUNDS FROM Cucumis melo LINN.
Objective: The present study deals with the qualitative identification of phytochemical constituents from Cucumismelo Linn fruits and seeds Method: The methanolic extract of both fruit and seed was subjected to phytoch...