OPTIMIZED TRI-LAYERED PULSATILE TABLET OF SALBUTAMOL FOR CHRONODELIVERY IN ASTHMA
Journal Title: Hygeia:journal for drugs and medicines - Year 2017, Vol 9, Issue 1
Abstract
Plan: The study was aimed to develop a tri-layered pulsatile tablet of salbutamol sulphate for Chrono therapeutic delivery in bronchial asthma. Incidence of asthma is greatest in the early morning hours referred as “morning dip”. Preface: A formulation which could deliver the drug in the right concentration just prior to the attack could effectively control the condition and staining drug release thereafter will further enable the dosage as once a day unit. Methodology: This formulation consists of three layers with the first layer for sustain release and the second for the burst release after a predetermined lag time and the third layer determines the lag time. A novel two stage coating was employed to achieve the burst followed by sustained release. The bottom and the sides of the tablets were coated with an insoluble polymer, ethyl cellulose which acted as a cage for the dosage form all sides except the top. The caged unit was finally dip coated with pH sensitive polymer eudragit L. Outcome: The formulation was optimized by Box-Behnken design and the composition suggested by the design expert successfully achieved the lag time of 5 hrs and cumulative drug release of 32% and 95% respectively at 6th and 24th hours
Authors and Affiliations
CHACKO A. J, JYOTI HARINDRAN
Keywords
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- EP ID EP332833
- DOI 10.15254/H.J.D.Med.9.2017.161
- Views 81
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