Formulation & Evaluation of Ciprofloxacin Solid Dispersion Controlled Release Floating Capsules for Solubility Improvement
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 3
Abstract
Solid dispersions in water soluble carriers have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was formulation & evaluation of controlled release floating capsule of ciprofloxacin with improved solubility & dissolution rate. In present study solid dispersion using various carriers like mannitol & lactose in different ratios were prepared by solvent evaporation method. The prepared solid dispersions were characterized for drug content, solubility & dissolution rate. The dissolution rate substantially improved for ciprofloxacin from its solid dispersions compared with pure drug. Dissolution rate increased with increase in carrier content. The dissolution rate was increased 3 folds with solid dispersions containing 1:4 of drug: lactose. The granules of ciprofloxacin solid dispersion containing 1:4 of drug: lactose ratio was prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.
Authors and Affiliations
Gaurav Subhash Katore| Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, S. J. Bidkar| Assistant Professor, Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, G. Y. Dama| Principal, Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India
Keywords
Related Articles
- EP ID EP15594
- DOI -
- Views 388
- Downloads 22
Establishment of social clubs as a potential tool to educate adolescents living in urban field practice area of Shri BM Patil Medical college, Bijapur
Introduction: Globally half of the new HIV/AIDS cases are among the age group of 15 to 24 years and the greatest hope for changing the course of epidemic lies with the same agegroup. Within this age group, adolescents...
Formulation and Dissolution Study of Valsartan Immediate Release Tablets
In the present study, design of oral immediate release tablets of Valsartan by direct compression technique was carried out. The main aim and objective of the work is to formulate immediate release tablets using differ...
Antibacterial activity of Crotalaria pallida Aiton. (Fabaceae)
Crotalaria pallida Aiton. Fabaceae has been used for the treatment of various diseases like. The aim of the present study is to assess antibacterial activity of methanolic leaves extract of Crotalaria pallida Aiton. Es...
Formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet as a novel drug delivery system
Objective: To deal with the formulation, characterization and pharmacological evaluation of anti-inflammatory polyphyto matrix tablet containing Carica papaya, Vitex negundo, Moringa oleifera and Boswellia serrata used a...
Microscopical evaluation of leaf of Maytenus emarginata
Microscopical investigation was carried out on leaves of Maytenus emarginata (Willd.) Ding Hou belongs to family celastraceae, is an evergreen tree that tolerates various types of stresses of the desert, locally known as...