Formulation & Evaluation of Ciprofloxacin Solid Dispersion Controlled Release Floating Capsules for Solubility Improvement
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 3
Abstract
Solid dispersions in water soluble carriers have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was formulation & evaluation of controlled release floating capsule of ciprofloxacin with improved solubility & dissolution rate. In present study solid dispersion using various carriers like mannitol & lactose in different ratios were prepared by solvent evaporation method. The prepared solid dispersions were characterized for drug content, solubility & dissolution rate. The dissolution rate substantially improved for ciprofloxacin from its solid dispersions compared with pure drug. Dissolution rate increased with increase in carrier content. The dissolution rate was increased 3 folds with solid dispersions containing 1:4 of drug: lactose. The granules of ciprofloxacin solid dispersion containing 1:4 of drug: lactose ratio was prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.
Authors and Affiliations
Gaurav Subhash Katore| Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, S. J. Bidkar| Assistant Professor, Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, G. Y. Dama| Principal, Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India
Keywords
Related Articles
- EP ID EP15594
- DOI -
- Views 368
- Downloads 22
Solventless coating for Tablets: An alternative to conventional coating technique
There are many ways to coat tablets. Coatings are a very important part in the formulation of pharmaceutical dosage form to achieve excellent formulation quality (e.g., color, texture, mouth feel, and taste masking), p...
D-Pencillamine induced nephrotic syndrome in 11-year old girl with wilson disease: A case report
D-pencillamine and zinc remains the first line of treatment for Wilson’s disease in India. Membranous glomerulopathy is most commonly associated with nephrotic syndrome secondary to d penicillamine but isolated cases...
Establishment of social clubs as a potential tool to educate adolescents living in urban field practice area of Shri BM Patil Medical college, Bijapur
Introduction: Globally half of the new HIV/AIDS cases are among the age group of 15 to 24 years and the greatest hope for changing the course of epidemic lies with the same agegroup. Within this age group, adolescents...
Current Pharmaceutical Situation (Services) in Yemen and Future Challenges
This article deals with Yemen’s current pharmaceutical scenario and possible future challenges that it may face. The manuscript provides an overview of health services particularly pharmaceutical services and the cri...
Isolation, Identification and quantitative analysis of Ellagic acid: a tannin compound from Helicteres isora
Plant derived secondary metabolites have widely attracted humans with great interest due to their immense medicinal and pharmacological properties. Ellagic acid, a natural phenolic compound found in many fruits exhibits...