Formulation & Evaluation of Ciprofloxacin Solid Dispersion Controlled Release Floating Capsules for Solubility Improvement
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2017, Vol 5, Issue 3
Abstract
Solid dispersions in water soluble carriers have attracted considerable interests as a mean of improving the dissolution rate & hence possibly bioavailability range of hydrophobic drugs. The poor solubility of ciprofloxacin leads to poor dissolution & hence variation in bioavailability. The purpose of present investigation was formulation & evaluation of controlled release floating capsule of ciprofloxacin with improved solubility & dissolution rate. In present study solid dispersion using various carriers like mannitol & lactose in different ratios were prepared by solvent evaporation method. The prepared solid dispersions were characterized for drug content, solubility & dissolution rate. The dissolution rate substantially improved for ciprofloxacin from its solid dispersions compared with pure drug. Dissolution rate increased with increase in carrier content. The dissolution rate was increased 3 folds with solid dispersions containing 1:4 of drug: lactose. The granules of ciprofloxacin solid dispersion containing 1:4 of drug: lactose ratio was prepared by wet granulation method using polymer such as ethyl cellulose & HPMC. The prepared granules were evaluated to preformulation studies such as angle of repose (18.41-24.22), bulk density, tapped density, compressibility index (11.31-12.75) & hausner’s ratio. All the parameters shows that the granules having good flow properties. These granules had converted into the capsule forms. Then the formulated capsules were taken to the evaluation studies such as weight variation, release study, buoyancy & floating duration (more than 6 hrs.). We can conclude that all the parameters were within the acceptable limits.
Authors and Affiliations
Gaurav Subhash Katore| Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, S. J. Bidkar| Assistant Professor, Department of Pharmaceutics, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India, G. Y. Dama| Principal, Department of Pharmacognosy, Sharadchandra Pawar College of Pharmacy, Dumberwadi, Pune, India
Keywords
Related Articles
- EP ID EP15594
- DOI -
- Views 342
- Downloads 22
Mineral contents from some fabaceous plant species of Rajasthan desert
Evaluation of mineral contents from three selected plant species of Fabaceae family growing in arid region of Rajasthan Desert was carried out. The roots, shoots and fruits of Clitoria ternatea, Sesbania bispinosa and...
Optimisaton techniques: a futuristic approach for formulating and processing of pharmaceuticals
Designing and formulating an ideal pharmaceutical product is a very tedious job for a formulator as it comprises of multiple objectives. The traditional method followed for years is not only expensive and time consuming...
VACTERL association in the newborn
VACTERL association is a non-random association of birth (congenital) defects that affects multiple median and para-median structures. VACTERL association is a useful acronym to denote vertebral abnormalities (V), anal...
Cyclic Changes In The Hypothalamo Neurohypophysial System of Xenentodon Cancila (HAM.)
The presence of functional hypothalamo-hypophysial neurosecretory system in vertebrates has led to revise earlier views regarding the hypothalamus-pituitary relationship. The hypothalamo-neurohypophysial system which c...
Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-small cell lung cancer
Aberrant increased expression and activation of receptor tyrosine kinases occur frequently in human carcinomas. Several small molecules targeting receptor tyrosine kinases, which have crucial roles in the growth factor...