Formulation & evaluation of Ofloxacin sustained release matrix tablet
Journal Title: Journal of Drug Discovery and Therapeutics - Year 2014, Vol 2, Issue 7
Abstract
The present study aimed to formulate and evaluate sustained release matrix tablets of Ofloxacin to achieve sustained drug release. Sustained release matrix tablets of Ofloxacin were prepared by wet granulation method using HPMC K4M as polymer, Avicel PH 102 (MCC) as filler and starch as binder. The prepared tablets were evaluated for hardness, weight variation, friability and drug content uniformity. It was found that the results comply with official standards. The in vitro release was studied using pH 1.2 acidic buffer and pH 6.8 phosphate buffer. The in vitro release study revealed that the prepared tablets were able to sustain the drug release. The release kinetics studies showed that the release was diffusion controlled and the n values obtained from the Korsmeyer-Peppas model showed that the release mechanism was non-Fickian type. Stability studies indicated that the developed tablets were stable and retained their pharmaceutical properties at 40°C (RH = 75%) for a period of 3 months.
Authors and Affiliations
Sujit Bose*| Department of Pharmacy, Siddhi Vinayak College of Sciences & Hr. Education, MIA, Alwar, Rajasthan-301001, India., Amandeep Kaur| Department of Pharmacology, G.H.G Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab-141104, India., Anu Mahajan| Department of Pharmaceutics, G.H.G Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab-141104, India., Manpreet Kaur| Department of Pharmaceutical Chemistry, G.H.G Khalsa College of Pharmacy, Gurusar Sadhar, Ludhiana, Punjab-141104, India.
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