FORMULATION INVITRO EVALUATION OF FAST DISSOLVING TABLETS OF LEVOCETIRIZINE DIHYDROCHLORIDE BY DIRECT COMPRESSION METHOD
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2017, Vol 6, Issue 2
Abstract
The demand for fast dissolving tablets has been growing during the last decade, especially for elderly and children who have swallowing difficulties. In the present work, fast dissolving tablets of Levocetirizine dihydrochloride, were prepared using sodium starch glycolate, sodium croscarmellose and crospovidone as super disintegrants, by the direct compression method. The tablets prepared were evaluated for various parameters including weight variation, hardness, friability, in vitro dispersion time, drug-polymer interaction, drug content water absorption ratio, wetting time, in vitro drug release, FTIR studies. The tablets prepared by the direct compression method had a weight variation in the range of 245 mg to 257 mg, which is below ± 7.5%, a hardness of 3.6 kg/cm2 to 4.5 kg/cm2, percentage friability of 0.46% to 0.73%, in vitro dispersion time of 18 s to 125 s, drug content uniformity of between 98.12% and 100.03%, a water absorption ratio of 67% to 87%, wetting time of 32 sec. to 64 sec., and an in vitro drug release of 53.92% - 98.82% within 15 min. The IR spectral analysis study showed no drug interaction with formulation additives of the tablet, and the formulations indicated no significant changes in hardness, friability, drug content or in vitro drug release. Based on the results, F6 formulation was considered as the desired formulation which contains crosspovidone as a super disintegrant.Fast dissolving tablets of Levocetirizine dihydrochloride have enhanced dissolution and will lead to improved bioavailability and more effective therapy.
Authors and Affiliations
Smily Priyanka, D. R. Brahmareddy
Keywords
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