COMPRESSIONAL PROPERTY STUDY OF DIGITARIA IBURUA (POACEAE) STARCHES
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 1
Abstract
Objective: This research work was aimed at determining the compression behavior of Digitaria iburua starch (DS) and acid hydrolyzed starch (MCS) using gelatin (GEL) as a standard compressible excipient. Methods: DS was extracted from the grains and then acid hydrolyzed to produce MCS. The particle density of DS, MCS and GEL were determined. Compacts (500 mg) of DS, MCS and GEL were produced by compressing the powder at various pre-determined pressures (56.625-311.438 MNm-2). The compression properties of the compacts were evaluated using the Heckel equation. Results: The Heckel plots for DS, MCS and GEL possessed nonlinear curves at the lower and higher pressures and linear curves in between. The mean yield pressure (PY) was high which is indicative of higher resistance against plastic deformation. Modification of DS to MCS increased PY for deformation with corresponding decline in onset of deformation and lesser total deformation. The PY, the relative density at zero pressure (DO) and the total deformation occurring in the powder (DA) values ranked in the following order; GEL>MCS>DS. The fragmentation tendency of the powder (DB) ranked in this order; MCS>GEL>DS. Conclusion: DS and MCS fragmented on compaction. DS and MCS are not suitable direct compressible excipient.
Authors and Affiliations
Gideon o. Okpanachi, hassan musa, adamu b. Isah
Keywords
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