SYNTHESIS, EVALUATION OF ANTIMICROBIAL ACTIVITIES OF SOME (E)-1-(5-CHLORO-2-HYDROXYPHENYL)-3-PHENYLPROP-2-EN-1-ONE COMPOUNDS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2016, Vol 5, Issue 4
Abstract
Objective: The aim of this study was to synthesize some substituted(E)-1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one compounds using crossed-aldol condensation reaction of 5-chloro-2-hydroxy acetophenone with various substituted benzaldehydes in the presence of sodium hydroxide (base) and to characterize the by their analytical, physical and spectroscopic data. Also we aim to study their antimicrobial activities. Methods: Crossed-aldol condensation reaction was used for synthesizing some substituted (E)-1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one compounds. They were characterized by ultraviolet (UV), infrared (IR) and nuclear magnetic resonance (NMR) spectral data. The Bauer-Kirby method was used for evaluation of antimicrobial activities of the synthesized compounds. Results: Yields of synthesized compounds were more than 80%. Few substituted (E)-1-(5-chloro-2-hydroxyphenyl)-3-phenylprop-2-en-1-one compounds gave excellent antimicrobial activities, whereas others gave poor antimicrobial activities. Conclusion: The synthesized 3-NO2 substituted compound has shown excellent activity against five out of ten bacterial strains. The synthesized H (parent), 3-Br, 4-Br and 3-F substituted compounds have shown excellent activity against four out of ten bacterial strains. The 4-OCH3 and 3-OC6H5 substituted compounds have shown excellent activity against one out of five fungal strains.
Authors and Affiliations
vanangamudi . , s. balaji, v. manikandan, r. senbagam, m. rajarajan, g. thirunarayanan
Keywords
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