FORMULATION OF CONTROLLED RELEASE MATRIX TABLET OF DICLOFENAC SODIUM USING CROSS LINKED STARCH UREA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 3
Abstract
The présent works aims to develop controlled release matrix tablet of diclofenac sodium with modified starch cross linked starch urea as an sustained release polymer and to evaluate the prepared dosage form for physical parameters like weight variation, hardness, friability and drug content. Cross linked starch urea is modified starch introducing desirable alterations in the starch structure so that its behavior is predictable and controllable. In the current study, the influence of different concentration of polymer on erosion of matrix system was studied with a view to develop controlled release formulation of diclofenac sodium. The Diclofenac sodium tablet was prepared by wet granulation method. The result from in vitro drug release study indicated that formulation F1 to F6 were with different polymer concentration and F5 found to release the drug at a steady state over an extended period of time up to 24 h.
Authors and Affiliations
Neetu Gautam, Prerna Mishra
Keywords
Related Articles
- EP ID EP164514
- DOI 10.7897/2230-8407.07329
- Views 109
- Downloads 0
A VALIDATED SIMULTANEOUS HPLC METHOD FOR DETERMINATION OF ASSAY OF TEMAZEPAM AND FORCED DEGRADATION STUDIES
A new HPLC method was developed for selective and simultaneous determination of of Teamazepam. The developed method is also applicable for the related substances determination in bulk drugs. The chromatographic separatio...
FORMULATION AND EVALUATION OF IMMEDIATE RELEASE VENLAFAXINE HCL TABLETS: COMPARATIVE STUDY OF SUPER DISINTEGRANT AND DILUENTS
The objective of the present study was to formulate and evaluate immediate release Venlafaxine HCl tablets: comparative study of different superdisintegrants (croscarmellose sodium, crospovidone and sodium starch glycola...
SCREENING OF MULTI DRUG RESISTANT ESCHERICHIA COLI FROM URINARY TRACT INFECTED PATIENTS
Antimicrobial drug resistance is one of the major threats due to widespread use of antimicrobial drugs in general population and has been increasing in clinical significance over recent years. The prevalence of resistanc...
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLET OF GLICLAZIDE
Mouth dissolving tablets is the fast growing and highly accepted drug delivery system, convenience of self administration, compactness and easy manufacturing. Gliclazide is a second generation anti-diabetic drug used for...
A REVIEW ON BAUHINIA VARIEGATA LINN
Bauhinia variegata linn. (Kachnar/Raktakanchan) is a medium sized tree with hairy branches belonging to family Leguminosae. The various parts of trees like flowers buds, flowers, stem bark, stem, leaves, seeds and root a...