FORMULATION OF CONTROLLED RELEASE MATRIX TABLET OF DICLOFENAC SODIUM USING CROSS LINKED STARCH UREA
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2016, Vol 7, Issue 3
Abstract
The présent works aims to develop controlled release matrix tablet of diclofenac sodium with modified starch cross linked starch urea as an sustained release polymer and to evaluate the prepared dosage form for physical parameters like weight variation, hardness, friability and drug content. Cross linked starch urea is modified starch introducing desirable alterations in the starch structure so that its behavior is predictable and controllable. In the current study, the influence of different concentration of polymer on erosion of matrix system was studied with a view to develop controlled release formulation of diclofenac sodium. The Diclofenac sodium tablet was prepared by wet granulation method. The result from in vitro drug release study indicated that formulation F1 to F6 were with different polymer concentration and F5 found to release the drug at a steady state over an extended period of time up to 24 h.
Authors and Affiliations
Neetu Gautam, Prerna Mishra
Keywords
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