FORMULATION SPAN 40 NIOSOME OF AQUEOUS FRACTION MENIRAN (PHYLLANTHUS NIRURI L.)
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 11
Abstract
Meniran (Phyllanthus niruri L.) is used for many conditions such as diabetes mellitus, hypertension, obesity and hyperlipidemia. The active constituens to which the antidiabetic activity of P. niruri L. has been attributed include flavonoids. Flavonoid glycosides have been the physical problem of delivering a drug across the membrane. The aim of the present study were total flavonoids content and to develop a niosomal formulation for aqueous fraction of P. niruri L. Methode in this study are analysis the total flavonoids content and characterization of the niosomes. The total flavonoids content from extract and aqueous fraction with rutin standard were 12.32±0.53 and 20.07±1.23 (RE/g) respectively. The niosomes preparation used a thin layer film hydration technique with solven hydration 0.5; 1; 2; 3 and 4% aqueous fraction of P. niruri L. Niosomes span 40 can be hydration in temperature 80oC for 20 minutes to concentration 0,5% and 1-3% for 50 minutes while 4% can’t released. The particle size of the optimal delivery system prepared with Span 40 100 μmol and cholesterol 20 μmol was about 5 μm.
Authors and Affiliations
Sri luliana
Keywords
Related Articles
- EP ID EP639905
- DOI -
- Views 155
- Downloads 0
P53: THE GUARDIAN OF GENOME, APOPTOSIS, AND ITS ROLE IN CARCINOGENESIS
The p53 protein also labeled as tumor protein 53 (or TP53) is one of the best known tumor suppressor protein encoded by the tumor suppressor gene TP53, located in the short arm of chromosome 17.(17 P13.1). Since its disc...
EPISTAXIS IN CHILDREN: COMPARITIVE ANALYSIS OF TOPICAL ANTISEPTIC AND CAUTERY VERSUS TOPICAL ANTISEPTIC ALONE
Objective: To evaluate and compare different modalities in management of simple recurrent epistaxis in children. Patients and methods: A total of 148 children (age 5-14 years) presented to ENT clinic with recurrent epist...
CLIMAX IN PREVALENCE OF IRON DEFICIENCY ANAEMIA AMONG PREGNANT WOMEN IN RIVERS STATE
Pregnancy, a physiological state in women of reproductive ages, is associated with an increased requirement of macro and micro nutrients. Iron is a vital micro nutrient for human population because it plays a key role in...
THE PREVALENCE OF DEPRESSION IN MULTIPLE SCLEROSIS PATIENTS AND ITS RELATIONSHIP WITH SOME DEMOGRAPHIC AND CLINICAL VARIABLES IN AHVAZ GOLESTAN HOSPITAL
Introduction: The prevalence of depression in MS patients is significantly higher than this amount in general population or patients with general medical conditions except MS. Due to the high prevalence of depression in...
CLINICAL ADVANTAGES OF USING HYDROGEN WATER GENERATOR
Molecular hydrogen has been regarded as an inactive, nonfunctional molecule in our body. We overturned this concept and proposedthe potential for preventive and therapeutic application by proving that H2reacts to strong...