Fraxinus excelsior and Vitamin E Combination for NAFLD (FEVEN)
Journal Title: The Indian Practitioner - Year 2018, Vol 71, Issue 11
Abstract
Objective: The combination of Vitamin E 400 IU soft gelatin capsule and Fraxinus excelsior 500 mg soft gelatin capsules (Ensules+) were evaluated for safety and efficacy as compared to Vitamin E 400 IU soft gelatin capsules in patients with NAFLD. Material and Methods: The prospective, open-label, comparative, randomized, single centre clinical trial was conducted by Macleods Pharmaceuticals in collaboration with Muktai Hospital, Nashik. Total of 24 NAFLD patients were divided into 2 groups and received either Vitamin E (400 IU) soft gelatin capsule or Ensules+(combination of Vitamin E 400 IU and Fraxinus excelsior 500mg) soft gelatin capsules BID for 8 weeks. The Grades of Liver steatosis after 8 weeks, liver function test (AST, ALT, ALP, bilirubin levels) and serum lipid profile (Tg, Tc, HDL, LDL) was evaluated at the end of the study. Result: Nonalcoholic fatty liver disease (NAFLD) patients with Vitamin E and Ensules+ therapy BID for 8 weeks revealed no significant difference in the physical parameters like mean body temperature, pulse rate and blood pressure from baseline to end of the study. Significant improvement in lipid profile and liver function parameters were observed in both the groups at the end of the study as compared to the baseline. The % improvement in Tc and LDL (3.27 % and 4.93% respectively) from baseline were significant in Ensules+ group (B) as compared to Vitamin E group (A) (1.10% and 1.13 % respectively), also HDL levels were significantly elevated (1.34 %) in Ensules+ group. Percentage improvement in liver function parameters in group A patients treated with Ensules+ Capsule had higher AST (53.64%), ALT (59.53%) ALP (38.43%) and Bilirubin levels (56.54%) as compared to group B patients treated with vitamin E capsules. 5 Patients treated with Ensules+ (combination of Vitamin E 400IU and Fraxinus excelsior 500mg) soft gelatin capsules) showed significant regression with the fatty liver disease at the end of the study. Conclusion: Combination of Vitamin E and Fraxinus excelsior (Ensules+) capsule were found to be better in improving the lipid profile and liver function parameters in patients with NAFLD. To the best of our knowledge, this is the first study which compares the combination with Vitamin E capsule and found to be more effective in treating patients with NAFLD
Authors and Affiliations
Chetan Patil, Ashish Mungantiwar, Priyanka Shrivastava
Keywords
Related Articles
- EP ID EP584117
- DOI -
- Views 45
- Downloads 0
Interventional study of Type 2 diabetes mellitus among Perimenopausal women in an urban slum community of Mumbai
A community based interventional study on type 2 diabetes was undertaken among perimenopausal women in the urban slum community of Cheetah Camp, an urban slum community of Mumbai. Such an interventional study was never d...
Clinical Profile of Chronic Kidney Disease Patients: A Hospital Based Study
Introduction: Chronic kidney disease is an important non-communicable disease, which is affecting the whole world. Incidence of chronic kidney disease is increasing, affecting the health care system as well as economy of...
A case of Vasmol Poisoning: Monitoring and treatment
We report a case of suicidal ingestion of hair dye that presented with cervicofascialoedema and later developed rhabdomyolysis and liver cell injury. Our patient improved with symptomatic management
Meditation And Healthy Ageing For Seniors
Ageing, though a graceful period, is associated with problems related to physical and mental health, social isolation and financial crunch. This review aims at highlighting the efficacy of meditation in promoting health...
Evaluating Acute Chest Pain in A Primary Care Setting
In the primary care setting, approximately 1% of all visits are for chest pain. Though heart disease is the leading cause of death globally, yet < 2.5% of patients presenting to a primary care office with chest pain will...